Actively Recruiting
Eosinopenia in Severe COPD Exacerbation
Led by Northumbria Healthcare NHS Foundation Trust · Updated on 2026-04-14
200
Participants Needed
1
Research Sites
127 weeks
Total Duration
On this page
Sponsors
N
Northumbria Healthcare NHS Foundation Trust
Lead Sponsor
N
Newcastle University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline stable state in patients who are admitted to hospital with a severe exacerbation of COPD and associated eosinopenia. The main aims of the study are to: 1. Identify demographic, physiological and clinical factors independently associated with admission eosinopenia in patients with a severe exacerbation of COPD 2. Assess the time to recovery from eosinopenia to stable BEC following a severe exacerbation of COPD
CONDITIONS
Official Title
Eosinopenia in Severe COPD Exacerbation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted to hospital with primary clinical diagnosis of exacerbation of COPD
- Smoking history of at least 10 pack years
- Airflow obstruction: FEV1/FVC ratio < 0.7 confirmed on historic or inpatient spirometry
- Capacity to give informed consent to participate
- Eosinopenia on admission (for time to recovery analysis)
- Uneventful recovery: no further systemic corticosteroids or emergency hospital admissions within six weeks following COPD exacerbation (for time to recovery analysis)
You will not qualify if you...
- Parasitic infection, systemic fungal infection (excluding nails or skin), eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or other conditions causing high eosinophil count
- Active malignancy
- Maintenance oral prednisolone or other systemic steroids, anti-interleukin 5 therapy, or other medications affecting eosinophils
- Poor venous access
- Investigator-confirmed history of asthma
- Non-COPD health problems that may interfere with study participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Northumbria Healthcare NHS Foundation Trust
North Shields, United Kingdom
Actively Recruiting
Research Team
S
Stephen Bourke, MBChB, PhD
CONTACT
P
Peter Ireland, MBBS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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