Improving Care for Children and Adolescents with Eosinophilic Esophagitis by Using Non-Invasive Biomarkers to Reduce Diet Restrictions and Endoscopies

What this Trial Is About

Researchers are working to improve care for children and adolescents with eosinophilic esophagitis EoE, a condition affecting the esophagus. This project aims to reduce the need for complex elimination diets and frequent endoscopies by studying existing and new non-invasive biomarkers. The study focuses on predicting how well patients respond to food elimination and tracking healing without invasive procedures. The study involves collecting samples like blood, esophageal brushes, aspirates, and feces to measure various biomarkers, including eosinophil counts, IgE levels, cytokines, eosinophil-derived neurotoxin, and circulating microRNAs. These biomarkers are compared to biopsy results, which are the current gold standard, to validate less invasive methods. This observational study is conducted by pediatric units in Norway and includes biobank sampling for new biomarker research. Participants will be monitored over time with assessments of these biomarkers to predict disease activity and healing. The main outcome measured is active eosinophilic esophagitis indicated by eosinophil counts in tissue biopsies after 12 months. The study seeks to reduce invasive procedures and dietary restrictions, improving quality of life. Participation involves providing samples and undergoing clinical evaluations with no treatment intervention, and the study will continue until the end of 2025.

Eosinophilic Esophagitis: Towards Improved Management