High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.
J Pablo Abonia, Ting Wen, Emily M Stucke...
https://pubmed.ncbi.nlm.nih.gov/23608731/Actively Recruiting
Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2026-03-18
500
Participants Needed
1
Research Sites
265 weeks
Total Duration
This research focuses on Eosinophilic Gastrointestinal Disorders EGIDs, including Eosinophilic Esophagitis, Gastritis, Gastroenteritis, and Colitis. It aims to better understand the symptoms patients experience during treatment, their quality of life, the diseases progression under different treatments, and any links between EGIDs and connective tissue disorders. The study is observational and seeks to gather detailed information to support future targeted treatments. Participants will be part of a registry collecting data and biological samples during routine care procedures such as endoscopies or colonoscopies. These samples will be stored indefinitely in a biorepository for research to explore disease mechanisms and severity. The study includes both patients with confirmed EGIDs and those suspected of having the condition undergoing evaluation. During the study, researchers will collect clinical information, patient-reported symptoms and quality of life measures, endoscopic and histologic findings, physical exam results, and molecular data over an average of six months to one year. This comprehensive data will help characterize EGIDs and assess disease activity and treatment responses. Participation involves follow-up through standard care visits, with no additional treatments assigned by the study team.
CONDITIONS
Eosinophilic Gastrointestinal Disorders Registry
A
Angela Anthony
M
Mary Riordan
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Ann & Robert H Lurie Children's Hospital of Chicago
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 day
Participants undergo standard of care evaluation, including endoscopy or colonoscopy with biopsies, to diagnose or assess suspected eosinophilic gastrointestinal disorders.
1 visit (in-person)
Duration - Average of 6 months to 1 year
Participants are observed and data are collected on clinical, endoscopic, histologic, molecular, and patient-reported measures to understand disease progression and treatment response.
Visits as part of routine care over 6 to 12 months
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Lead Sponsor