What this Trial Is About

This research aims to find out how quickly the drug rocuronium works to relax muscles in patients aged 80 and older. Older adults often face higher risks during surgery due to changes in their heart, liver, kidneys, and body composition. Because rocuronium usually takes longer to work in elderly patients, this study tests whether giving a dose of ephedrine before rocuronium can speed up its effect and help with safer intubation during anesthesia. Participants will receive either ephedrine at a dose of 0.15 mg/kg or a placebo (saline) during anesthesia induction. After this, they receive rocuronium at 0.6 mg/kg to relax muscles for intubation. Researchers will measure the time it takes from giving rocuronium until muscle relaxation is complete using a device that monitors nerve responses. The study is blinded and randomized, meaning neither the patients nor the researchers know which treatment is given. Throughout the study, participants will be monitored closely with neuromuscular tests during surgery to track how fast rocuronium works. The main outcome is the onset time of rocuronium within one hour. The study includes patients undergoing planned surgeries who can provide informed consent and understand Danish. Safety and treatment effects will be observed during the anesthesia period.

Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients