Actively Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
Led by Pfizer · Updated on 2025-07-17
160
Participants Needed
73
Research Sites
229 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study treatment works in the study) of the study medicine (called nirmatrelvir/ritonavir) for potential treatment of coronavirus disease 2019 (COVID-19). The study medicine will be given to patients under 18 years of age with COVID-19 that are not hospitalized but are at risk for severe disease.
CONDITIONS
Official Title
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants aged 0 to under 18 years, able to swallow for some participants
- Confirmed SARS-CoV-2 infection within 72 hours before enrollment
- Initial onset of COVID-19 symptoms within 5 days before enrollment with at least one symptom present at enrollment
- At least one characteristic or underlying medical condition increasing risk for severe COVID-19 illness
You will not qualify if you...
- History of or current need for hospitalization for COVID-19 treatment
- Total bilirubin level 2 times or more above the upper limit of normal (except for Gilbert's syndrome)
- Receiving dialysis or having known moderate to severe kidney impairment
- Suspected or confirmed active systemic infection other than COVID-19
- History of allergy or contraindication to any component of the study medicine
- Current or expected use of medications highly dependent on CYP3A4 for clearance or strong CYP3A4 inducers
- Have received or expect to receive antibody treatment, antiviral treatment, or convalescent COVID-19 plasma for COVID-19
- Currently participating in another interventional clinical study with an investigational drug or device, including for COVID-19
- Female participants who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 73 locations
1
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
Active, Not Recruiting
2
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Active, Not Recruiting
3
Kaiser Permanente
Los Angeles, California, United States, 90027
Active, Not Recruiting
4
UCLA David Geffen School of Medicine
Los Angeles, California, United States, 90095
Not Yet Recruiting
5
UCLA
Los Angeles, California, United States, 90095
Not Yet Recruiting
6
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Active, Not Recruiting
7
Life Spring Research Foundation
Miami, Florida, United States, 33130
Actively Recruiting
8
Children's Healthcare of Atlanta - Arthur M. Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
9
Rophe Adult and Pediatric Medicine/SKYCRNG
Union City, Georgia, United States, 30291
Terminated
10
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Active, Not Recruiting
11
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
12
Louisiana State University Health Sciences Shreveport
Shreveport, Louisiana, United States, 71101
Actively Recruiting
13
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
14
Boston Medical Center
Boston, Massachusetts, United States, 02118
Active, Not Recruiting
15
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States, 01655
Terminated
16
Childrens Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, United States, 55404
Not Yet Recruiting
17
SKY Integrative Medical Center/SKYCRNG
Ridgeland, Mississippi, United States, 39157
Active, Not Recruiting
18
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110
Not Yet Recruiting
19
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Not Yet Recruiting
20
Children's Hospital & Medical Center
Omaha, Nebraska, United States, 68114
Terminated
21
University of New Mexico Hospital, COVID-19 Research Clinic
Albuquerque, New Mexico, United States, 87102
Terminated
22
University of New Mexico Clinical and Translational Science Center
Albuquerque, New Mexico, United States, 87106
Terminated
23
Suny University at Buffalo
Buffalo, New York, United States, 14203
Not Yet Recruiting
24
Advanced Specialty Care
Commack, New York, United States, 11725
Not Yet Recruiting
25
Stony Brook Medicine Clinical Research Center
East Setauket, New York, United States, 11733
Not Yet Recruiting
26
Cohen Children's Medical Center
New Hyde Park, New York, United States, 11040
Not Yet Recruiting
27
Columbia University Irving Medical Center
New York, New York, United States, 10032
Not Yet Recruiting
28
Stony Brook University
Stony Brook, New York, United States, 11794
Not Yet Recruiting
29
Upstate Health Care Center
Syracuse, New York, United States, 13202
Not Yet Recruiting
30
Crouse Physicians Office Building
Syracuse, New York, United States, 13210
Not Yet Recruiting
31
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Not Yet Recruiting
32
Upstate Golisano Children's Hospital
Syracuse, New York, United States, 13210
Not Yet Recruiting
33
Clinical and Translational Research Center
Chapel Hill, North Carolina, United States, 27514
Terminated
34
investigational Drug Services Pharmacy, UNC Hospitals
Chapel Hill, North Carolina, United States, 27514
Terminated
35
UNC Children's Hospital
Chapel Hill, North Carolina, United States, 27514
Terminated
36
UNC Global Clinical Research North
Chapel Hill, North Carolina, United States, 27514
Terminated
37
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States, 27599
Terminated
38
UNC Children's Raleigh
Raleigh, North Carolina, United States, 27607
Terminated
39
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Active, Not Recruiting
40
UH Landerbrook Health Center
Mayfield Heights, Ohio, United States, 44124
Active, Not Recruiting
41
UH Parma Medical Center
Parma, Ohio, United States, 44129
Active, Not Recruiting
42
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Not Yet Recruiting
43
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Active, Not Recruiting
44
The Miriam Hospital-Clinical Trials
Providence, Rhode Island, United States, 02904
Active, Not Recruiting
45
Avera McKennan Hospital & University Health Center
Sioux Falls, South Dakota, United States, 57105
Terminated
46
Avera Research Institute - Sioux Falls
Sioux Falls, South Dakota, United States, 57108
Terminated
47
Texas Children's Hospital
Houston, Texas, United States, 77030
Not Yet Recruiting
48
Biopharma Informatic, LLC
McAllen, Texas, United States, 78503
Terminated
49
Consano Clinical Research, LLC
Shavano Park, Texas, United States, 78231
Actively Recruiting
50
University of Utah
Salt Lake City, Utah, United States, 84108
Not Yet Recruiting
51
МHAT "Sveti Ivan Rilski" Gorna Oryahovitsa
Gorna Oryahovitsa, Bulgaria, 5100
Not Yet Recruiting
52
"Specialized Hospital for Active Treatment of Pneumo-Physiatric Diseases Dr. Dimitar Gramatikov -
Rousse, Bulgaria, 7002
Not Yet Recruiting
53
Medical Center-1-Sevlievo EOOD
Sevlievo, Bulgaria, 5400
Not Yet Recruiting
54
DCC "Alexandrovska"
Sofia, Bulgaria, 1431
Terminated
55
Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases Vratsa EOOD
Vratsa, Bulgaria, 3000
Not Yet Recruiting
56
Tokyo Metropolitan Children's Medical Center
Fuchū, Tokyo, Japan, 183-8561
Not Yet Recruiting
57
Osaka City General Hospital
Osaka, Japan, 534-0021
Not Yet Recruiting
58
Instituto Nacional de Pediatria
Mexico City, Mexico City, Mexico, 04530
Not Yet Recruiting
59
Hospital Infantil de Mexico Federico Gomez
Mexico City, Mexico City, Mexico, 06720
Active, Not Recruiting
60
JM Research SC
Cuernavaca, Morelos, Mexico, 62290
Active, Not Recruiting
61
Fundación Santos y De la Garza Evia
Monterrey, Nuevo León, Mexico, 64710
Active, Not Recruiting
62
Eukarya Pharmasite S.C.
Monterrey, Nuevo León, Mexico, 64718
Terminated
63
Unidad de Atención Médica e Investigación en Salud
Mérida, Yucatán, Mexico, 97000
Active, Not Recruiting
64
Kohler & Milstein Research S.A. De C.V.
Mérida, Yucatán, Mexico, 97070
Active, Not Recruiting
65
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatán S.
Mérida, Yucatán, Mexico, 97130
Active, Not Recruiting
66
Centenario Hospital Miguel Hidalgo
Aguascalientes, Mexico, 20259
Not Yet Recruiting
67
Arké SMO S.A de C.V
Veracruz, Mexico, 91900
Active, Not Recruiting
68
Sociedad de Metabolismo y Corazon S.C.
Veracruz, Mexico, C.P. 91900
Active, Not Recruiting
69
San Miguel Medical
Trujillo Alto, Puerto Rico, 00976
Not Yet Recruiting
70
Worthwhile Clinical Trials
Benoni, Gauteng, South Africa, 1500
Active, Not Recruiting
71
CRISMO Research Centre
Germiston, Gauteng, South Africa, 1401
Active, Not Recruiting
72
Botho Ke Bontle Health Services
Pretoria, Gauteng, South Africa, 0184
Not Yet Recruiting
73
St. George's Hospital
London, England, United Kingdom, SW17 0QT
Active, Not Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
5
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