Actively Recruiting
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
Led by Reproductive Medicine Associates of New Jersey · Updated on 2025-04-17
100
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient centrifugation (DGC) preparation for intracytoplasmic sperm injection (ICSI) in patients undergoing in vitro fertilization treatment (IVF) of their infertility.
CONDITIONS
Official Title
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing first IVF cycle
- Planning single embryo transfer
- Planning preimplantation genetic testing for aneuploidy (PGT-A) of embryos
- Female partner age between 18 and under 42 years at start of ovarian stimulation cycle
- Anti-Mullerian Hormone (AMH) level at least 1.2 ng/mL
- Antral Follicle Count (AFC) at least 8
- Follicle Stimulating Hormone (FSH) level 12 IU/L or less
- At least 4 mature eggs (metaphase II oocytes) retrieved at egg collection
- Intention to transfer the morphologically best quality, chromosomally normal embryo at frozen embryo transfer
You will not qualify if you...
- Contraindication to IVF treatment
- Need for preimplantation genetic testing for single gene disorders, chromosomal translocations, or other detailed genetic analyses
- Male partner with azoospermia or oligozoospermia (less than 500,000 total motile sperm in recent semen analysis within one year)
- Use of previously frozen sperm for ICSI
- Use of donor sperm
- Male partner with Y-chromosome microdeletion
- Male partner with any karyotype other than 46,XY
- Male partner requiring surgically retrieved sperm (testicular or epididymal)
- Uncorrected hydrosalpinges communicating with the uterus
- Endometrial insufficiency (prior cycle with endometrial thickness less than 6 mm or persistent endometrial fluid)
- Use of donor eggs or embryos
- Use of gestational carriers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Reproductive Medicine Associates of New Jersey
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
Research Team
C
Caroline Clinical Research Nurse, BSN, RN
CONTACT
C
Christine Director of Research Operations, MS, BSN, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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