Study of Factors Linked to the Formation, Growth, and Rupture of Brain Aneurysms in China A Retrospective Multi-Center Hospital-Based Investigation

What this Trial Is About

Researchers are investigating the factors linked to the formation, growth, and rupture of intracranial aneurysms IA in the Chinese population. This study is retrospective and multi-center, analyzing data from hospital stroke centers in China to better understand what exposures may increase the risk of IA and improve detection and screening methods. The study reviews large-scale electronic medical records and imaging data, including digital subtraction angiography DSA, cranial computed tomography angiography CTA, and magnetic resonance angiography MRA. These images are carefully evaluated by radiologists and neurosurgeons to confirm IA presence. Patient exposures are extracted from medical records using natural language processing, assuming absence if not documented. Participants medical data, including demographics and imaging results, are analyzed retrospectively to identify factors associated with IA incidence from 2010 to 2024. The primary outcome measure is the occurrence of intracranial aneurysms. This study aims to provide valuable insights for future research by thoroughly examining exposures and risk factors in patients aged 18 to 80 years.

Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China