Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study.
Jiancheng Lin, Xin Feng, Zhuohua Wen...
https://pubmed.ncbi.nlm.nih.gov/40542179Actively Recruiting
Age: 18Years - 80Years
All Genders
Healthy Volunteers
ID06456814
Epidemiological Insights Into the Formation, Progression, and Rupture of Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
Led by Zhujiang Hospital · Updated on 2024-06-13
30000
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
Sponsors
Z
Zhujiang Hospital
Lead Sponsor
B
Beijing Tiantan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the factors linked to the formation, growth, and rupture of intracranial aneurysms (IA) in the Chinese population. This study is retrospective and multi-center, analyzing data from hospital stroke centers in China to better understand what exposures may increase the risk of IA and improve detection and screening methods. The study reviews large-scale electronic medical records and imaging data, including digital subtraction angiography (DSA), cranial computed tomography angiography (CTA), and magnetic resonance angiography (MRA). These images are carefully evaluated by radiologists and neurosurgeons to confirm IA presence. Patient exposures are extracted from medical records using natural language processing, assuming absence if not documented. Participants' medical data, including demographics and imaging results, are analyzed retrospectively to identify factors associated with IA incidence from 2010 to 2024. The primary outcome measure is the occurrence of intracranial aneurysms. This study aims to provide valuable insights for future research by thoroughly examining exposures and risk factors in patients aged 18 to 80 years.
CONDITIONS
Brief Title
Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
Who Can Participate
Age: 18Years - 80Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Diagnosis of intracranial aneurysm (ruptured or unruptured) or exclusion by digital subtraction angiography (DSA), cranial computed tomography angiography (CTA), or magnetic resonance angiography (MRA)
- Age between 18 and 80 years old
- Complete demographic data including age and sex
- Medical records officially archived
You will not qualify if you...
- Missing data on age, sex, or hypertensive status
- Age below 18 or above 80 years
- Pregnancy
- History of intracranial arteriovenous malformation, Moyamoya disease, polycystic kidney disease, Ehlers-Danlos syndrome, Gronblad-Strandberg syndrome, or Marfan syndrome
- Suspicion of dissecting or mycotic aneurysms or aneurysm-like lesions not clearly distinguishable on imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Retrospective data covering 2010 to 2024
Participants undergo cerebrovascular imaging procedures including digital subtraction angiography (DSA), cranial computed tomography angiography (CTA), or magnetic resonance angiography (MRA) to identify the presence or absence of intracranial aneurysms.
Long-term Monitoring
Duration - Retrospective observation spanning multiple years
Participants' medical records and imaging data are reviewed retrospectively using natural language processing and other methods to assess exposures related to aneurysm formation, progression, and rupture.
Trial Site Locations
Total: 1 location
1
Zhujiang Hospital
Guangzhou, China
Actively Recruiting
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Research Team
C
Chuanzhi Duan, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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