Actively Recruiting

Age: 18Years - 80Years
All Genders
ID06422052

Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms

Led by Shanghai Jiao Tong University School of Medicine · Updated on 2024-12-30

2242

Participants Needed

26

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are conducting a multicenter, prospective observational study to investigate how often patients with Helicobacter pylori infection experience dyspeptic symptoms, such as indigestion. The study also aims to follow these patients after they undergo treatment to eradicate H. pylori to see how their dyspeptic symptoms improve over time. This research intends to guide better diagnosis and treatment strategies for patients with H. pylori infection and related digestive discomfort. Participants diagnosed with H. pylori infection confirmed by breath tests or gastroscopy will complete an epidemiological questionnaire and a Functional Dyspepsia Symptom Diary (FDSD) to record their symptoms. Patients who have dyspepsia and successfully clear the infection will be followed up at 2 months and again at 6 months to assess if their symptoms have improved. The study does not involve any experimental drugs or treatments but focuses on observation and symptom tracking. During the study, patients will provide basic health information and record their digestive symptoms in the diary. Researchers will track the occurrence of dyspepsia at the start and monitor symptom relief after treatment. The follow-up periods at 2 and 6 months after eradication therapy will help measure symptom changes. Participants may be involved for several months, contributing to a better understanding of the natural history of H. pylori-related dyspepsia and treatment outcomes.

CONDITIONS

Brief Title

Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Male or female patients aged 18-80 years
  • Diagnosed with Helicobacter pylori infection by 13C/14C breath test or gastroscopy
  • Treatment-naive for Helicobacter pylori infection
  • Able and willing to participate and provide informed consent
Not Eligible

You will not qualify if you...

  • Under 18 or over 80 years old
  • Have organic digestive diseases such as active peptic ulcer, gastroesophageal reflux, gastrointestinal bleeding, pancreatitis, cholecystitis, gallstones, intestinal obstruction, or inflammatory bowel disease
  • Have alarm symptoms like melena, vomiting blood, anemia, or unexplained weight loss
  • Pregnant or breastfeeding women
  • History of cancer
  • History of subtotal gastrectomy
  • Severe organ dysfunction or congenital diseases such as advanced heart failure, liver failure, uremia, respiratory failure, hemophilia, or Wilson's disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - 1 day

Participants undergo tests to confirm Helicobacter pylori infection and complete epidemiological questionnaires and symptom diaries to assess dyspepsia symptoms.

1 visit (in-person)

Long-term Monitoring

Duration - 6 months

Participants who have successfully eradicated Helicobacter pylori infection are followed up to monitor relief of dyspepsia symptoms.

2 follow-up visits at 2 months and 6 months (in-person)

Trial Site Locations

Total: 26 locations

1

Chongqing Daping Hospital

Chongqing, Chongqing Municipality, China

Actively Recruiting

2

The Ninth People's Hospital of Chongqing

Chongqing, Chongqing Municipality, China

Actively Recruiting

3

The People's Hospital of Kaizhou District, CQ

Chongqing, Chongqing Municipality, China

Actively Recruiting

4

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

Actively Recruiting

5

The People's Hospital of Wuwei

Wuwei, Gansu, China

Actively Recruiting

6

The First People's Hospital of Qinzhou

Qinzhou, Guangxi, China

Actively Recruiting

7

The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, China

Actively Recruiting

8

Yongcheng People's Hospital of Henan Province

Shangqiu, Henan, China

Actively Recruiting

9

Xuchang Central Hospital

Xuchang, Henan, China

Actively Recruiting

10

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Actively Recruiting

11

Baotou Central Hospital

Baotou, Inner Mongolia, China

Actively Recruiting

12

Dalian Friendship Hospital

Dalian, Liaoning, China

Actively Recruiting

13

The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Actively Recruiting

14

Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China, 200127

Actively Recruiting

15

Ruijin Hospital Luwan Branch

Shanghai, Shanghai Municipality, China

Actively Recruiting

16

Shanghai Construction Group Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

17

Shanghai East Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

18

Shanghai Putuo Liqun Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

19

Shanghai Songjiang Central Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

20

West China Fourth Hospital, Sichuan University

Chengdu, Sichuan, China

Actively Recruiting

21

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Tianjing, Tianjing, China

Actively Recruiting

22

The Second People's Hospital of Kashgar, Xinjiang

Kashgar, Xinjiang, China

Actively Recruiting

23

Second People's Hospital of Jinning District, Kunming City

Kunming, Yunnan, China

Actively Recruiting

24

Ningbo Hangzhou Bay Hospital

Ningbo, Zhejiang, China

Actively Recruiting

25

The People's Hospital of Shengzhou

Ningbo, Zhejiang, China

Actively Recruiting

26

Shengzhou People's Hospital

Shaoxing, Zhejiang, China

Actively Recruiting

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Research Team

H

Hong Lu, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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