Actively Recruiting
Epidural Stimulation After Neurologic Damage
Led by University of Minnesota · Updated on 2026-04-08
100
Participants Needed
1
Research Sites
542 weeks
Total Duration
On this page
Sponsors
U
University of Minnesota
Lead Sponsor
M
Minnesota Office of Higher Education
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord injury.
CONDITIONS
Official Title
Epidural Stimulation After Neurologic Damage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 22 years of age or older
- Able to undergo the informed consent or assent process
- Stable, motor-complete paraplegia
- Spinal cord injury located between C6 and T10
- ASIA A or B Spinal Cord Injury Classification
- Medically stable based on the principal investigator's judgment
- Intact segmental reflexes below the injury site
- More than 1 year since initial injury and at least 6 months since any spinal instrumentation
- Willing to attend all scheduled appointments
You will not qualify if you...
- Diseases or conditions increasing the risk of spinal cord injury surgery (e.g., cardiopulmonary issues)
- Unable to stop antiplatelet or anticoagulation medications around surgery
- Significant autonomic dysfunction preventing rehabilitation or assisted standing, or history of stroke or heart attack linked to autonomic dysreflexia
- Abnormal tilt table test results with syncope, presyncope, or systolic blood pressure under 50 or over 200
- Other conditions preventing participation in testing or rehabilitation as judged by the principal investigator
- Current or expected need for opioid pain medications or pain limiting full rehabilitation participation
- Significant mental illness as judged by the principal investigator
- Botulinum toxin injections within the past 6 months
- Voluntary movements detected in both lower limbs during EMG testing
- Unhealed spinal fractures
- Significant contractures
- Presence of pressure ulcers
- Recurrent urinary tract infections resistant to antibiotics
- Current pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
D
David Darrow, MD MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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