Actively Recruiting
Epigenetic Profiling and Liquid Biopsy: Perspectives for Personalized Medicine in Meningioma Patients - MIND
Led by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Updated on 2026-02-10
210
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
Sponsors
F
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Lead Sponsor
U
University of Milan
Collaborating Sponsor
AI-Summary
What this Trial Is About
Meningiomas are the most common primary intracranial tumors. Current treatment relies on surgical resection and radiotherapy, but molecular predictors for recurrence are lacking. This study aims to investigate epigenetic features, specifically histone post-translational modifications (PTMs) and DNA methylation, to stratify patients. The study involves a retrospective cohort to define an epigenetic signature and a prospective cohort to validate it in tissues and liquid biopsies (plasma/EVs).
CONDITIONS
Official Title
Epigenetic Profiling and Liquid Biopsy: Perspectives for Personalized Medicine in Meningioma Patients - MIND
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 years or older
- First diagnosis of uni-focal meningioma of the convexity
- Macroscopical total resection (Simpson 1-3)
- Surgery performed between 2007 and 2016 (retrospective cohort only)
- Availability of FFPE sample and medical records (retrospective cohort only)
You will not qualify if you...
- Genetic syndromes
- Diffuse Meningeal Meningiomatosis
- Patients who underwent experimental treatment in neo-adjuvant setting
- Previous surgical or medical treatment for another meningioma (prospective cohort only)
- Positive oncological history such as breast cancer (prospective cohort only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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