Actively Recruiting
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Led by Unity Health Toronto · Updated on 2025-12-11
3790
Participants Needed
8
Research Sites
288 weeks
Total Duration
On this page
Sponsors
U
Unity Health Toronto
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.
CONDITIONS
Official Title
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Out-of-hospital cardiac arrest treated by paramedics
- Initial recorded cardiac rhythm of ventricular fibrillation or pulseless ventricular tachycardia, or AED shock on first analysis administered or witnessed by EMS
- Established intravenous vascular access
You will not qualify if you...
- Known or apparent age under 18 years
- Initial recorded cardiac rhythm not ventricular fibrillation or pulseless ventricular tachycardia, or AED shock not administered or confirmed by paramedics
- Cardiac arrest due to a clear non-cardiac cause such as trauma, burns, drug overdose, drowning, anaphylaxis, or sudden asphyxiation
- Administration of epinephrine by intramuscular, endotracheal tube, or intraosseous routes
- Prisoners or persons in police custody
- Known allergy or sensitivity to epinephrine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
British Columbia Emergency Health Services (BCEHS)
Victoria, British Columbia, Canada, V8W 9P1
Actively Recruiting
2
Peel Regional Paramedic Services
Brampton, Ontario, Canada, L6T 4B9
Actively Recruiting
3
Middlesex-London Paramedic Service
London, Ontario, Canada, N6E 1R4
Actively Recruiting
4
Halton Region Paramedic Services
Oakville, Ontario, Canada, L6M 3L1
Actively Recruiting
5
Ottawa Paramedic Services
Ottawa, Ontario, Canada, K1H 1E2
Actively Recruiting
6
Superior North Emergency Medical Services
Thunder Bay, Ontario, Canada, P7B 4X6
Actively Recruiting
7
Essex-Windsor Emergency Health Services
Windsor, Ontario, Canada, N9A 1N6
Actively Recruiting
8
Medavie Health Services West
Saskatoon, Saskatchewan, Canada, S7J 4M2
Actively Recruiting
Research Team
T
Theresa Aves, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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