Actively Recruiting

Phase Not Applicable
Age: 18Years +
MALE
NCT04861194

EREctile Function Preservation for Prostate Cancer Radiation Therapy (ERECT)

Led by UMC Utrecht · Updated on 2026-03-05

70

Participants Needed

1

Research Sites

316 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Single-arm phase II trial of 70 men with low- or intermediate-risk prostate cancer receiving magnetic resonance guided adaptive radiotherapy (MRgRT) in 5 fractions of 7.25 Gy, additionally sparing the neurovascular bundles, the internal pudendal arteries, the corpora cavernosa, and the penile bulb for erectile function preservation.

CONDITIONS

Official Title

EREctile Function Preservation for Prostate Cancer Radiation Therapy (ERECT)

Who Can Participate

Age: 18Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Histologically confirmed adenocarcinoma of the prostate
  • Low-risk or intermediate-risk prostate cancer according to NCCN risk categories (T1c-T2c, Gleason score 6-7, PSA less than 20 �b5g/L)
  • Patients with pT1a/b tumor diagnosis after transurethral resection of the prostate (TURP)
  • International Index of Erectile Function-5 (IIEF-5) score between 17 and 25
  • Karnofsky performance score between 70 and 100
  • Signed written informed consent
Not Eligible

You will not qualify if you...

  • Use of (neo-)adjuvant androgen deprivation therapy
  • High-risk prostate cancer according to NCCN risk categories (T3a or Gleason score 8-10 or PSA greater than 20 �b5g/L)
  • Patients with "bulky" iT3 tumor diagnosis
  • Previous pelvic irradiation or radical prostatectomy
  • Clinical evidence of metastatic disease
  • Unable to undergo MRI
  • Incompetent to sign written informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University Medical Center Utrecht

Utrecht, Utrecht, Netherlands, 3584CX

Actively Recruiting

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Research Team

F

Frederik R Teunissen, MD

CONTACT

J

Jochem RN van der Voort van Zyp, MD PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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