Actively Recruiting
The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)
Led by Abramson Cancer Center at Penn Medicine · Updated on 2025-11-28
25
Participants Needed
4
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will target patients with gastrointestinal (GI) malignancy who present to any of 4 Penn Medicine emergency departments (EDs) with intractable abdominal pain. We will offer eligible patients an erector spinae plane block (ESPB), a regional anesthesia technique which is already offered to such patients in the ED at the University of Pennsylvania Healthy System (UPHS), for their intractable abdominal pain. We will compare the outcomes of this prospective cohort of patients to a matched historical control of patients with GI malignancy who were treated in the ED during the same time period as recruitment, but who were not recruited to partake in the study and who were managed with standard of care. Opioid consumption as measured by total milligram morphine equivalents (MMEs) over a 24-hour period and hospital length of stay (LOS) will be compared between cohorts. Additionally, for the ESPB cohort, pain level pre/post ESPB, and functionality and satisfaction with pain management at 24 hours will also be examined.
CONDITIONS
Official Title
The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients age > 18 years old with GI malignancy presenting to a Penn Medicine emergency department with intractable abdominal pain
- Same-day or recent CT scan of the abdomen or pelvis showing that abdominal pain is likely due to a malignant source
You will not qualify if you...
- Allergy to ropivacaine or history of local anesthetic systemic toxicity
- Pregnancy
- Incarcerated status
- Admission for serial abdominal examinations to determine surgical course
- Altered mental status or inability to consent for the procedure
- Hemodynamic instability
- Previously enrolled in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
2
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
3
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
4
Hospital of the University of Pennsylvania -- Cedar Avenue
Philadelphia, Pennsylvania, United States, 19143
Actively Recruiting
Research Team
U
Umar Aulia, AB
CONTACT
M
Michael Shalaby, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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