Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05623722

Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury

Led by Jing Cai, MD · Updated on 2025-09-08

116

Participants Needed

1

Research Sites

209 weeks

Total Duration

On this page

Sponsors

J

Jing Cai, MD

Lead Sponsor

Z

Zhongshan People's Hospital, Guangdong, China

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study is a prospective, multicenter, parallel-group, open-label, randomized controlled clinical trial. Sepsis is defined as organ dysfunction induced by infections. And sepsis and gastrointestinal injury can be the leading cause for each other. Our previous study showed erector spinae plane block improved the organ dysfunctions in patients with AGI. The aim of the clinical trial is to investigate erector pinae plane block improves the organ dysfunction in septic patients with acute gastrointestinal injury.

CONDITIONS

Official Title

Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Septic patients with acute gastrointestinal injury grade II or III
  • Age over 18 years
  • Expected to stay in the ICU for at least 3 days or longer
Not Eligible

You will not qualify if you...

  • Mean arterial pressure less than 65 mmHg after fluid resuscitation, or need for intravenous norepinephrine dose greater than 0.5 bcg/kg/min to maintain normal pressure
  • Heart rates less than 50 beats/min or moderate-to-severe atrioventricular block without a pacemaker
  • Contraindications for erector spinae plane blocks, such as infection at puncture site, spinal diseases, or immobilization
  • Primary gastrointestinal disorders requiring surgery like mechanical intestinal obstruction, massive hemorrhage, or perforation
  • Gastrointestinal surgery within one week before enrollment
  • Neuromuscular disorders
  • Coagulation abnormalities: prolonged activated prothrombin time or prothrombin time by 2 folds, or platelet count less than 50d7109/L
  • End-stage malignant tumor or cachexia
  • History of allergy to amide anesthetics
  • Known pregnancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Department of Intensive Care Medicine of Zhujiang Hospital,Southern Medical University

Guangzhou, Guangdong, China, 510282

Actively Recruiting

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Research Team

J

Jing Cai, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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