Adverse events associated with postoperative opioid analgesia: a systematic review.
Michelle Wheeler, Gary M Oderda, Michael A Ashburn...
https://pubmed.ncbi.nlm.nih.gov/14622770Actively Recruiting
Phase Not Applicable
Age: 0 - 18Years
All Genders
ID04153994
Pediatric Scoliosis Surgery: Enhanced Recovery With Erector Spinae Plane Blockade Using Surgically Placed Catheters
Led by Stanford University · Updated on 2025-05-01
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying pain management after spinal fusion surgery for idiopathic scoliosis in children and adolescents. The trial evaluates the use of the erector spinae plane block (ESPB), a new regional anesthesia technique, to improve pain control and reduce opioid use after surgery. The study also investigates how this approach affects the body's inflammatory response related to acute pain after major surgery. Participants are randomly assigned to receive either the ESPB before surgery or the standard pain management care, which involves multiple types of pain relief including opioids. The ESPB involves injecting local anesthetic between muscles near the spine to block certain nerves, aiming to provide effective pain relief without affecting motor function. Patients who do not consent to randomization may still participate by allowing data and sample collection related to their perioperative care. During the hospital stay, which averages about five days, researchers will monitor length of stay, opioid use, lidocaine levels in the blood, patient-reported pain scores, and mobility after surgery. This study includes detailed assessments to understand the impact of ESPB on recovery and pain control in pediatric scoliosis surgery patients.
CONDITIONS
Brief Title
Erector Spinae Plane Blockade in Pediatric Scoliosis Surgery Patients
Who Can Participate
Age: 0 - 18Years
All Genders
Eligibility Criteria
You may qualify if you...
- ASA physical status I to III
- Diagnosed with idiopathic scoliosis
- Scheduled for single-stage posterior spinal instrumentation and fusion surgery
You will not qualify if you...
- Undergoing thoracoscopic tethering procedure
- Planned two-stage procedure
- Abnormal developmental profile
- Diagnosed with congenital or neuromuscular scoliosis
- Requiring pediatric intensive care unit admission
- Known allergy to lidocaine
- Known heart, kidney, or liver disease or dysfunction
- Pre-existing pain requiring regular analgesic medications
- Current psychiatric diagnosis such as anxiety, depression, or eating disorder
- Need for non-standard postoperative pain management
- History of seizures
- Unplanned staged surgical procedure
- Weight below 5th or above 85th percentile for age
- Diagnosis of porphyria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Through hospital stay, an average of 5 days
Participants receive an erector spinae plane blockade prior to their pediatric scoliosis surgery or standard care with multi-modal opioid pain management during their hospital stay.
Hospital stay visits for approximately 5 days
Trial Site Locations
Total: 1 location
1
Lucille Packard Children's Hospital
Palo Alto, California, United States, 94304
Actively Recruiting
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Research Team
B
Ban Tsui, MD
C
Chynna Villanueva, BS, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Perioperative Pain Management in Pediatric Spine Surgery.
Benjamin W Sheffer, Derek M Kelly, Leslie N Rhodes...
https://pubmed.ncbi.nlm.nih.gov/28870307The Erector Spinae Plane Block: A Novel Analgesic Technique in Thoracic Neuropathic Pain.
Mauricio Forero, Sanjib D Adhikary, Hector Lopez...
https://pubmed.ncbi.nlm.nih.gov/27501016Lumbar versus thoracic erector spinae plane block: Similar nomenclature, different mechanism of action.
Halil Cihan Kose, Selin Guven Kose, David Terence Thomas
https://pubmed.ncbi.nlm.nih.gov/29649625Continuous Bilateral Erector of Spine Plane Block at T8 for Extensive Lumbar Spine Fusion Surgery: Case Report.
Carlos Rodrigues Almeida, Ana Raquel Oliveira, Pedro Cunha
https://pubmed.ncbi.nlm.nih.gov/30758122Modified dual-injection lumbar erector spine plane (ESP) block for opioid-free anesthesia in multilevel lumbar laminectomy.
Jonathan Kline, Ki Jinn Chin
https://pubmed.ncbi.nlm.nih.gov/30392347Low thoracic erector spinae plane block for perioperative analgesia in lumbosacral spine surgery: a case series.
Josh P Melvin, Rudolph J Schrot, George M Chu...
https://pubmed.ncbi.nlm.nih.gov/29704223Chest tube-delivered bupivacaine improves pain and decreases opioid use after thoracoscopy.
Todd L Demmy, Chukwumere Nwogu, Patrick Solan...
https://pubmed.ncbi.nlm.nih.gov/19324125