Actively Recruiting
Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes
Led by Inova Health Care Services · Updated on 2025-09-18
140
Participants Needed
2
Research Sites
133 weeks
Total Duration
On this page
Sponsors
I
Inova Health Care Services
Lead Sponsor
E
Eastern Virginia Medical School
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to help identify the best antibiotic treatment for pregnant people when their water breaks prematurely (a condition abbreviated as PPROM). Current practice is to attempt to maintain the pregnancy until at least 34 weeks gestational age, when the risks of prematurity to the baby are lessened. Research shows that antibiotics help the pregnancy last longer, but there have been limited studies about which combination works best. Currently, both azithromycin and erythromycin are accepted antibiotic treatments, in addition to ampicillin and amoxicillin. Participants diagnosed with PPROM will be randomized to receive ampicillin and amoxicillin plus either azithromycin or erythromycin, in addition to the care they would normally receive. Studying these two drugs will help decide the best care for future patients with PPROM.
CONDITIONS
Official Title
Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant between 22 weeks 0 days and 32 weeks 6 days of gestation
- Water break confirmed by biochemical testing
- Membrane rupture occurred within the past 36 hours
- Cervical dilation 3 cm or less and 4 or fewer contractions within 60 minutes at admission
- Female aged 18 years or older and younger than 50 years
You will not qualify if you...
- Non-reassuring fetal heart tracing, vaginal bleeding, chorioamnionitis, or need for delivery at admission
- Allergy to penicillin, erythromycin, or azithromycin
- Multiple pregnancies
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Inova Fairfax Medical Campus
Falls Church, Virginia, United States, 22042
Actively Recruiting
2
Eastern Viriginia Medical School
Norfolk, Virginia, United States, 23507
Actively Recruiting
Research Team
A
Antonio Saad, MD, MBA
CONTACT
E
Ellen M Murrin, DO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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