Actively Recruiting
ESAT6/CFP10 Skin Testing for TB Infection in Rheumatologic Patients
Led by Chinese University of Hong Kong · Updated on 2025-09-10
100
Participants Needed
2
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the study is to pilot the application of a novel ESAT6/CFP10 (C-TST) skin test in rheumatologic disease patients prior to initiation of treatment with biologic and/or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD). This is a prospective observational study involving the recruitment of patients with rheumatologic diseases who are planned for initiation of b/tsDMARD. Eligible patients would undergo skin testing by the Mantoux technique with purified protein derivative (PPD) RT23 on one forearm and C-TST on the other, alongside routine blood sampling for Interferon-Gamma Release Assay. The skin test results would be read within 48-72 hours afterwards. Treatment of TB infection would be provided in accordance with current clinical guidelines, followed by regular clinical monitoring for 2 years. Analyses involve performance evaluation of C-TST, and decision-analytical modelling incorporating multiple Markov process to evaluate the impact of management by LTBI testing methods on clinical outcomes and health care costs.
CONDITIONS
Official Title
ESAT6/CFP10 Skin Testing for TB Infection in Rheumatologic Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Diagnosed with at least one classified rheumatologic disease
- Planned to receive biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) therapy
- Able to communicate in Chinese and/or English
You will not qualify if you...
- Diagnosis of active tuberculosis disease
- Currently receiving treatment for tuberculosis or latent tuberculosis infection
- Presence of concurrent mental illnesses
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
S.H. Ho Research Centre for Infectious Diseases
Hong Kong, Hong Kong, China, 0000
Actively Recruiting
2
S.H. Ho Research Centre for Infectious Diseases
Shatin, Hong Kong, Hong Kong, 0000
Not Yet Recruiting
Research Team
S
Shui Shan Lee, MD
CONTACT
H
Ho So, FRCP
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here