Actively Recruiting
ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Led by Western Sydney Local Health District · Updated on 2025-03-27
391
Participants Needed
1
Research Sites
546 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Colonic Laterally spreading lesions (LSL) =\> 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as per the Kudo classification of type V. In a recent report, risk factors for LSL with SMIC and no overt stigmata (i.e. covert SMIC) were described. Resection of these lesions 'en-bloc' can allow for better histological staging and potentially reduce the need for surgical resection.
CONDITIONS
Official Title
ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients referred for removal of large laterally spreading lesions in the colon
- Able to provide informed consent to participate in the trial
You will not qualify if you...
- Previous resection or attempted removal of the target adenoma lesion
- Visible signs of invasive cancer on endoscopy
- Younger than 18 years old
- Pregnancy
- Active inflammatory colonic conditions such as inflammatory bowel disease
- Use of anticoagulant or antiplatelet medications other than aspirin outside standard guidelines
- American Society of Anesthesiology (ASA) grade IV or V
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Westmead Endoscopy Unit
Westmead, New South Wales, Australia, 2145
Actively Recruiting
Research Team
M
Michael J Bourke, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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