Actively Recruiting
Esketamine Combined Pregabalin and Duloxetine for Postherpetic Neuralgia
Led by Beijing Tiantan Hospital · Updated on 2025-04-27
150
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
Sponsors
B
Beijing Tiantan Hospital
Lead Sponsor
B
Beijing Xiaotangshan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
To assess the 1-week effects and safety of esketamine in combination with pregabalin and duloxetine to relieve pain in patients with postherpetic Neuralgia(PHN).
CONDITIONS
Official Title
Esketamine Combined Pregabalin and Duloxetine for Postherpetic Neuralgia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age above 18 years
- Pain lasting more than 3 months after healing of herpes zoster rash
- Average pain score of at least 4 on a Numeric Rating Scale (0=no pain, 10=worst pain)
- Did not respond to or tolerate effective dose of pregabalin alone
You will not qualify if you...
- Obstructive sleep apnoea syndrome
- Receiving interventional treatments
- History of systemic immune diseases, organ transplantation, or cancers
- History of severe cardiopulmonary, hepatic, or renal dysfunction
- History of schizophrenia, epilepsy, myasthenia gravis, or delirium
- Current use of monoamine oxidase inhibitors (MAOIs)
- Untreated angle-closure glaucoma
- Increased intracranial pressure
- Comorbid hyperthyroidism or phaeochromocytoma
- Suspected or confirmed drug abuse
- Contraindications to esketamine, pregabalin, or duloxetine
- Communication difficulties
- Women preparing for pregnancy, pregnant, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
F
Fang Luo, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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