Registry Study to Identify Risk Factors and Genetic Markers for Esophageal Cancer and Related Disorders

What this Trial Is About

Researchers are investigating markers in blood and tissue that might signal the risk factors for developing and progressing esophageal cancer. The study enrolls patients with esophageal cancer, those at risk for it, and patients with non-cancerous esophageal disorders. By analyzing genetic and protein changes in tissues, the research aims to enable earlier detection and prevention. Understanding these genetic changes in tumors and nearby tissues may help identify tumor markers that can be detected before cancer develops. Participants will complete a questionnaire about their health, habits, and family medical history during a preoperative clinic visit. Blood samples will be collected before or during surgery and at routine follow-up visits. Tissue samples including biopsies from the esophagus, stomach, lymph nodes, tumors, and oral secretions may also be collected during surgical or endoscopic procedures. These samples will be stored securely for future genetic analysis. Additional samples may be collected during routine surveillance endoscopies when clinically indicated. Throughout the study, participants will provide medical history and biological samples, which will be used to study genetic changes associated with esophageal cancer. Data about cancer screening results and family cancer history might be collected and stored in a database for ongoing research. Samples will be kept indefinitely or until used up. The study may contact participants later to share relevant findings. Participation involves routine clinical visits, questionnaires, blood draws, and collection of biopsy tissues as part of standard medical care.

Esophageal Cancer Risk Registry