Actively Recruiting
Esophageal Cancer Risk Registry
Led by University of Pittsburgh · Updated on 2026-04-14
7000
Participants Needed
1
Research Sites
2687 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.
CONDITIONS
Official Title
Esophageal Cancer Risk Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Known or suspected esophageal or gastroesophageal junction malignancy
- Known Barrett's metaplasia
- Clinical management of symptomatic gastroesophageal reflux disease (GERD)
- Achalasia
- Hiatal hernia
You will not qualify if you...
- Elevated pre-operative bloodwork will not have the additional biopsies taken
- Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Cardiothoracic Surgery
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
J
Julie A Ward, BSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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