Actively Recruiting
Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy
Led by Children's Hospital of Philadelphia · Updated on 2025-05-29
75
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with IgE mediated food Allergy have elevated risk of eosinophilic esophagitis, and new therapies like oral immunotherapy (OIT) carry additional risk of Eosinophilic Esophagitis (EoE). The goal of this study is to investigate the Esophageal String Test (EST) as a screening tool for Eosinophilic Esophagitis (EoE) during OIT therapy. Investigators will compare the efficacy of the Esophageal String Test to symptom assessment using a validated patient reported symptom questionnaire, the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0. Investigators will utilize these tools to screen patients at their baseline visit prior to the start of OIT, then at the 3- and 6-month OIT follow-up visits.
CONDITIONS
Official Title
Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 7 to 18 years old, inclusive
- History of Immunoglobulin (IgE)-mediated food allergy
- Considering oral immunotherapy (OIT) for food allergies at Children's Hospital of Philadelphia
- Able and willing to swallow the esophageal capsule
- Parental or guardian permission and child assent if appropriate
- Willing to comply with all study procedures and available for the study duration
You will not qualify if you...
- Known or expected need for MRI imaging during the study period
- Known connective tissue disease
- Known eosinophilic disorder including eosinophilic gastrointestinal disorder and hypereosinophilic disorder
- Past history of caustic ingestion or esophageal injury
- History of esophageal surgery or dilation
- History of gastrointestinal motility disorder including esophageal achalasia
- History of inflammatory bowel disease
- Unwilling or unable to swallow the Esophageal String Test
- Oral or intravenous steroids in the past 60 days (excluding swallowed topical steroids)
- Participation in another clinical study that may interfere
- Pregnant or lactating females
- Limited English proficiency
- Considered potentially non-compliant by the Investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
S
Sharon A Carbonara, MS, BSN, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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