Actively Recruiting
A Randomized Trial Comparing Erector Spinae Plane Block Versus Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesic Efficacy in Patients Undergoing Coronary Artery Bypass Graft Surgery
Led by Kutahya Health Sciences University · Updated on 2026-05-13
64
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the postoperative pain relief and safety of two different nerve block techniques in adults aged 45 to 85 years undergoing elective coronary artery bypass graft (CABG) surgery. This randomized, double-blind, parallel-group study compares the ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) with the bilateral Serratus Posterior Superior Intercostal Plane Block (SPSIPB). The main goal is to measure pain levels after surgery using a Numeric Rating Scale at multiple time points up to 48 hours post-operation. Participants will receive either the ESPB or the SPSIPB before surgery under sedation. Each block involves injecting 20 mL of 0.25% bupivacaine on both sides, totaling 40 mL. All patients will also receive standard general anesthesia during the CABG procedure and a consistent postoperative multimodal pain management plan. The study groups are closely monitored for differences in pain control and medication use. Throughout the study, researchers will assess various factors including pain intensity at 2, 4, 8, 16, 24, and 48 hours after surgery, opioid consumption during and after the operation, need for additional pain relief, and recovery quality using the QoR-15 questionnaire. Other measures include extubation and mobilization times, lung function via incentive spirometry, ICU and hospital stay lengths, mortality, and any side effects related to the nerve blocks. Participation involves follow-up assessments up to 48 hours post-surgery with care monitored by the study team.
CONDITIONS
Brief Title
ESPB vs SPSIP for Postoperative Analgesia After CABG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 to 85 years
- Scheduled for elective coronary artery bypass graft surgery
- American Society of Anesthesiologists (ASA) class I, II, or III
- Written informed consent provided and agreement to participate
You will not qualify if you...
- Emergency surgery cases
- American Society of Anesthesiologists (ASA) class IV or V
- Known allergy to local anesthetics
- Blood clotting problems (platelet count <100,000/mm9, INR >1.5, aPTT >1.5 times normal)
- Infection at the site of nerve block injection
- Pregnancy
- Decline or inability to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants receive one of two ultrasound-guided nerve blocks preoperatively under sedation, followed by standardized general anesthesia for coronary artery bypass graft surgery and postoperative multimodal analgesia.
1 preoperative visit (in-person) and assessments up to 48 hours after surgery
Trial Site Locations
Total: 1 location
1
Kütahya Health Sciences University Hospital
Kütahya, Kütahya, Turkey (Türkiye), 43100
Actively Recruiting
Research Team
M
Merve Yaman, Assistant Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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