Actively Recruiting
Essential Amino Acid Supplementation for Femoral Fragility Fractures
Led by Michael C Willey · Updated on 2026-04-15
60
Participants Needed
2
Research Sites
128 weeks
Total Duration
On this page
Sponsors
M
Michael C Willey
Lead Sponsor
M
MEND
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the ability of EAA-based to increase skeletal muscle metabolic activity, reduce inflammation, and induce muscle fiber hypertrophy, as well as preserve skeletal muscle mass and physical performance up to 6 months after injury. Participants will be randomized in a 1:1 ratio to 1) standard of care (no dietary intervention) or 2) EAA-based supplementation.
CONDITIONS
Official Title
Essential Amino Acid Supplementation for Femoral Fragility Fractures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospital inpatient
- Age 65 years or older at admission
- Low-energy cause of injury
- Diagnosis of femur fracture (OTA 31, 32, or 33 fracture)
- Scheduled for surgical fixation
- Able to provide informed consent
You will not qualify if you...
- Part of a vulnerable population (e.g., incarcerated, non-English speaking)
- Cognitive impairment (Mini-Mental State Examination score 17 or below)
- Electrical medical implant (e.g., pacemaker, defibrillator, cochlear implant, insulin pump)
- Unable to walk before the injury
- Unable to eat by mouth or allergic to supplement ingredients (e.g., milk allergy)
- Concern about ability to complete follow-up
- Hemi or total joint replacement
- History of chronic kidney disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
2
Slocum Center for Orthopedics & Sports Medicine
Eugene, Oregon, United States, 97401
Not Yet Recruiting
Research Team
M
Michael C Willey, MD
CONTACT
A
Ashley S Kochuyt, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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