Study of Essential Amino Acid Supplement to Support Muscle Recovery After Surgery for Femoral Fragility Fractures in Older Adults

What this Trial Is About

This trial is studying older adults aged 65 and above who have experienced a femoral fragility fracture requiring surgical fixation. It aims to evaluate the effects of essential amino acid EAA-based supplementation on muscle health after surgery. Researchers want to see whether this supplementation can improve muscle activity, reduce inflammation, increase muscle fiber size, and help maintain muscle mass and physical function up to six months following the injury. Participants will be randomly assigned to one of two groups one receiving standard postoperative nutrition without dietary supplements, and the other receiving EAA-based oral supplements twice daily for four weeks starting within 72 hours after surgery. The EAA supplement used is MEND Repair and Recover. Both groups will receive usual care for their fractures, including operative fixation and standard nutrition. During the study, participants will attend seven visits over six months where various assessments will be conducted. These include muscle biopsies, blood tests for inflammation markers, body composition measurements, pain and physical function surveys, nutritional screenings, and physical performance tests like walking and balance evaluations. Researchers will also monitor supplement adherence, record living arrangements, and track any side effects or falls. The study will measure muscle cell concentrations, inflammation levels, muscle fiber size, and physical abilities at different time points to assess the impact of the supplementation.

Essential Amino Acid Supplementation for Femoral Fragility Fractures