Actively Recruiting
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Led by Ohio State University · Updated on 2026-04-21
88
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
U
United States Department of Agriculture (USDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
CONDITIONS
Official Title
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjective cognitive impairment
- Body mass index (BMI) of 30 kg/m2 or higher
- HbA1C less than 6.5%
You will not qualify if you...
- Diagnosis of cognitive impairment or dementia
- Montreal Cognitive Assessment (MoCA) score less than 26
- Current or past diagnosis of diabetes or use of diabetes medications
- Current diagnosis or treatment of cancer other than non-melanoma skin cancer
- Gastrointestinal diseases or surgeries affecting nutrient absorption or food tolerance
- Diagnosis of hyperthyroidism
- Food allergies or intolerances preventing consumption of study foods
- Any dietary restrictions contraindicating study foods or meals
- Use of oil supplements within 4 weeks before enrollment
- Pregnancy or breastfeeding
- Inability to access veins for blood draws
- Antibiotic use in the past month
- Use of psychostimulant or nootropic medications
- Current use of weight loss supplements, medications, or programs
- Severe or uncontrolled autoimmune diseases
- Severe kidney failure, liver cirrhosis, or certain lung diseases
- Heart disease events (stroke or heart attack) within 3 months prior to enrollment
- History of alcohol or drug abuse
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
M
Martha Belury, PhD, RDN
CONTACT
R
Rachel Cole
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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