Actively Recruiting
Led by SEARCH Research Foundation · Updated on 2026-04-27
777
Participants Needed
1
Research Sites
N/A
Total Duration
S
SEARCH Research Foundation
Lead Sponsor
A
Armed Forces Research Institute of Medical Sciences, Thailand
Collaborating Sponsor
Researchers are studying people with acute HIV infection to understand their clinical, immune, and virus-related characteristics. The study collects information on participants' demographics, behaviors, brain function, immune responses, and HIV types in blood and other body areas. It also tracks sexual contacts to offer testing and counseling. This observational study aims to help improve HIV vaccine development and understand how HIV affects the body early on. Participants who have acute HIV infection will be followed for up to 192 weeks with visits scheduled frequently in the first weeks and then every 12 weeks. Blood tests will monitor immune cells, virus levels, and other health markers. Optional procedures include collecting genital secretions, spinal fluid, brain scans, colon biopsies, genetic testing, and tracking sexual contacts for voluntary testing. During the study, participants will complete questionnaires about risk behaviors and provide samples for future research. Hospitalization is encouraged for the first few days for observation and easier follow-up. Researchers will measure the number of health events related to HIV and other conditions. They will also assess neurocognitive and immune changes, sexual contact patterns, and immune cells in the gut. The study may last around 6 years, including screening and follow-up.
CONDITIONS
Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population
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Complete this quick 3-step screening to check your eligibility
Duration - Up to 48 months
Participants are screened for eligibility to participate in the trial.
Duration - Up to 192 weeks (approximately 4 years)
Participants with acute HIV infection are followed prospectively to characterize early HIV infection and immune response. Blood tests and behavioral questionnaires are completed, with optional additional sample collections and imaging. Participants are encouraged to be hospitalized for the first 3 to 7 days for observation and follow-up.
Visits at week 0, days 2, 3, 5, 7, 10; weeks 2, 4, 8, 12, 16, 20, 24; then every 12 weeks until study end
Total: 1 location
1
Institute of HIV Research and Innovation (IHRI)
Bangkok, Bangkok, Thailand, 10330
Actively Recruiting
N
Nittaya Phanuphak, MD, PhD
N
Nitiya Chomchey
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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