Actively Recruiting
Establishing Best Treatment Strategy for T4 Esophageal Cancer
Led by National Cheng-Kung University Hospital · Updated on 2025-09-22
22
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy. The main questions it aims to answer are: * Does the new induction chemotherapy followed by chemoradiation reduce esophageal perforation rate? * Does the new induction chemotherapy followed by chemoradiation increase treatment response rate and patient survival? Researchers will analyze the above data to see if the new treatment approach works to treat T4 esophageal cancer. Participants will: * Receive induction chemotherapy for 4 to 8 cycles, followed by chemoradiation therapy if downstage to T3 * Visit the clinic once every week for checkups and tests * Keep a diary of their symptoms
CONDITIONS
Official Title
Establishing Best Treatment Strategy for T4 Esophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed esophageal squamous cell carcinoma
- Tumor or lymph nodes invade adjacent organs (T4 stage)
- Aged between 18-70 years old
- Eastern Cooperative Oncology Group (ECOG) performance status less than 2
- Hemoglobin e10 g/L, neutrophil count e2 x 10^3/L, platelet count e100 x 10^9/L, total bilirubin 1.5 mg/L, serum transaminases 105 U/L, creatinine clearance e40 mL/min
You will not qualify if you...
- Previous chemotherapy history
- Myocardial infarction within the last three months
- History of unstable angina, interstitial pneumonia, fibrotic lung disease, or severe emphysema
- Current other malignancies
- Uncontrolled infection
- Pregnancy or lactation
- Perforated esophagus at the time of diagnosis
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Cheng Kung University Hospital
Tainan, Taiwan, Taiwan, 704302
Actively Recruiting
Research Team
W
Wei-Lun Chang, PhD
CONTACT
C
Ching-Lin Wu, Master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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