Actively Recruiting
Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
Led by OHSU Knight Cancer Institute · Updated on 2025-09-25
50
Participants Needed
2
Research Sites
260 weeks
Total Duration
On this page
Sponsors
O
OHSU Knight Cancer Institute
Lead Sponsor
N
Natera, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study measures the levels of circulating tumor DNA (ctDNA) in patients with stage II-III rectal cancer before, during, and after treatment to find out if the presence or absence of ctDNA in patient's blood using the Signatera test can be used to gauge how different treatments may affect rectal cancer. ctDNA is DNA from the rectal cancer that is circulating in the blood. The purpose of this study is to understand if the way rectal tumors respond to standard treatment can be associated with varying levels of ctDNA.
CONDITIONS
Official Title
Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must provide written informed consent before any study-specific procedures or interventions are performed
- Participants aged 6 18 years
- Pathologically-confirmed stage II or III primary adenocarcinoma of the rectum: T3N0M0 - T4bN2M0
You will not qualify if you...
- Has radiologic evidence of distant metastases at the time of screening/enrollment
- Has received prior treatment for their rectal adenocarcinoma
- Requires or has received blood transfusion within 1 month of study enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
OHSU Knight Cancer Institute
Portland, Oregon, United States, 97239
Actively Recruiting
2
Fred Hutch
Seattle, Washington, United States, 98109
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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