Using Magnetic Resonance Spectroscopy MRS to Study Spinal Cord in Adults Assessing MRS for Detecting and Monitoring Spinal Cord Lesions and Effects of Radiation

What this Trial Is About

This research aims to establish the feasibility and detailed parameters of Magnetic Resonance Spectroscopy MRS for assessing spinal cord lesions in adults. The study focuses on mapping the total spine spectrum at short echo times to facilitate future comparisons for evaluating the malignant potential and grading of spinal cord lesions. Additionally, it will explore the reproducibility of the MRS protocol and investigate the effects of radiation on the spinal cord over different time frames in patients receiving craniospinal irradiation CSI. Participants include both healthy volunteers and patients with low volume leptomeningeal disease LMD undergoing standard CSI treatment. The study involves performing MRS scans on the spine to gather data on the spinal cord spectrum. This protocol will be applied to volunteers and patients to test its applicability and reproducibility. The study will collect data during and after radiation therapy to assess changes and support future trials focused on functional status and tumor grading. Participants will undergo MRS spine scans as the main study procedure. Researchers will monitor safety and any adverse events throughout the study period, which is expected to last up to one year. The study collects imaging data to evaluate spinal cord lesions and radiation effects while ensuring participant consent and ability to comply with procedures. This observational period will help establish MRS as a potential diagnostic tool for spinal cord assessment.

Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord