Actively Recruiting
Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord
Led by M.D. Anderson Cancer Center · Updated on 2026-03-04
13
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of Magnetic Resonance Spectroscopy (MRS) to assess spinal cord lesions in adults. The study aims to establish the feasibility and range of MRS for mapping the entire spine spectrum at short echo times. This will help compare results in patients to assess the malignant potential and grade of spinal cord lesions. The trial also plans to test the reproducibility of the MRS protocol and examine the effects of radiation on the spinal cord over time in patients receiving craniospinal irradiation for leptomeningeal disease (LMD). Participants include healthy adult volunteers and adult patients with low volume LMD undergoing craniospinal irradiation as part of their standard treatment. Both groups will receive MRS scans of the spine using the established protocol. The study is non-randomized and involves implementing the MRS technique on these two groups to gather data on its use and effects. The secondary objective is to provide data for future trials focused on functional status after radiation and tumor grading predictability using MRS. During the study, participants will undergo MRS spine scans and be monitored for safety and any adverse events throughout the study duration, averaging about one year. Researchers will assess the success and reproducibility of the MRS protocol and monitor the impact of radiation on the spinal cord at different times. Participants must consent and comply with study procedures, and safety will be closely followed until study completion.
CONDITIONS
Brief Title
Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years old
- Healthy volunteers with no malignancy, demyelinating disease, back pain, degenerative disease, or spinal cord lesions
- Patients with low volume leptomeningeal disease (LMD) confirmed by MR or CSF evidence
- Patients receiving craniospinal irradiation as part of standard LMD treatment
- Able to provide consent and comply with study procedures
- No spinal cord lesions other than LMD disease
You will not qualify if you...
- Individuals under 18 years old
- Pregnant or breastfeeding individuals
- History of cancer
- History of spinal cord lesions including malignant, demyelinating, or inflammatory conditions
- History of prior spinal surgery
- Presence of implantable devices
- Claustrophobia related to MRI
- Degenerative disease or spinal/back pain including myelopathy and radiculopathy
- Scoliosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants will undergo Magnetic Resonance Spectroscopy (MRS) scans of the spinal cord to test the feasibility and reproducibility of the protocol.
Multiple MRS scan visits over the course of the study
Duration - Up to 1 year
Participants are monitored for safety and adverse events related to the MRS scans through study completion.
Periodic safety assessments during the study period
Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77090
Actively Recruiting
Research Team
R
Rami Eldaya, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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