Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction.
Abhiram Prasad, Amir Lerman, Charanjit S Rihal
https://pubmed.ncbi.nlm.nih.gov/18294473Actively Recruiting
All Genders
ID03299569
Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study
Led by University of Aberdeen · Updated on 2025-03-24
800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Aberdeen
Lead Sponsor
N
NHS Tayside
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand Takotsubo cardiomyopathy, a condition that mimics a heart attack but occurs without blocked coronary arteries, often triggered by intense emotional or physical stress. The study seeks to identify all cases of Takotsubo cardiomyopathy in Scotland since 2010 and evaluate its frequency, causes, and health outcomes compared to heart attack patients and the general population. Public Health Scotland will collect data by identifying patients coded with relevant heart disease diagnoses and confirming Takotsubo cases through clinical records at participating health boards. The study includes a group of Takotsubo patients, a matched group from the general population, and a matched group of myocardial infarction patients for comparison. Data linkage will allow assessment of treatments, health events, and risks over more than a decade. Participants' medical records will be reviewed both retrospectively and going forward to track health outcomes, medication use, and survival rates. Researchers will focus on measuring mortality and morbidity over a 13-year period, including specific causes of these outcomes. This observational study does not involve treatment but collects important information to better understand Takotsubo cardiomyopathy and its impact on patients.
CONDITIONS
Brief Title
Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- All patients diagnosed with Takotsubo cardiomyopathy
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Surveillance
Duration - Up to 13 years
Participants who have been diagnosed with Takotsubo cardiomyopathy or myocardial infarction are observed through electronic data linkage to assess outcomes, prescribing, and prediction scores.
Trial Site Locations
Total: 1 location
1
Cardiac Research Office
Aberdeen, Scotland, United Kingdom, AB25 2ZD
Actively Recruiting
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Research Team
D
Dana Dawson, MD, MRCP
A
Amelia Rudd, HND
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
Christian Templin, Jelena R Ghadri, Johanna Diekmann...
https://pubmed.ncbi.nlm.nih.gov/26332547Four-year recurrence rate and prognosis of the apical ballooning syndrome.
Ahmad A Elesber, Abhiram Prasad, Ryan J Lennon...
https://pubmed.ncbi.nlm.nih.gov/17662398Frequency of Takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome.
Fridolin Sy, Jagroop Basraon, Hong Zheng...
https://pubmed.ncbi.nlm.nih.gov/23683950Neurohumoral features of myocardial stunning due to sudden emotional stress.
Ilan S Wittstein, David R Thiemann, Joao A C Lima...
https://pubmed.ncbi.nlm.nih.gov/15703419Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?
Dana K Dawson, Christopher J Neil, Anke Henning...
https://pubmed.ncbi.nlm.nih.gov/25499134Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI.
Christopher Neil, Thanh Ha Nguyen, Angela Kucia...
https://pubmed.ncbi.nlm.nih.gov/22791656Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels.
M Madhavan, B A Borlaug, A Lerman...
https://pubmed.ncbi.nlm.nih.gov/19468013Pre-morbid psychiatric and cardiovascular diseases in apical ballooning syndrome (tako-tsubo/stress-induced cardiomyopathy): potential pre-disposing factors?
Matthew R Summers, Ryan J Lennon, Abhiram Prasad
https://pubmed.ncbi.nlm.nih.gov/20170799Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Cross-Disorder Group of the Psychiatric Genomics Consortium
https://pubmed.ncbi.nlm.nih.gov/23453885