Actively Recruiting
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Led by University Medical Center Groningen · Updated on 2026-05-14
10000
Participants Needed
2
Research Sites
245 weeks
Total Duration
On this page
Sponsors
U
University Medical Center Groningen
Lead Sponsor
A
A.O.U. Città della Salute e della Scienza
Collaborating Sponsor
AI-Summary
What this Trial Is About
Machine perfusion (MP) has become routine clinical practice in liver transplantation. However, as the field has matured, direct randomized comparisons between distinct MP modalities have become increasingly impractical, given that donor and graft characteristics often predetermine the optimal preservation strategy. Consequently, many studies continue to reference historical benchmark cohorts from the pre-perfusion era, or use risk scores developed before routine utilization of MP. These cohorts, while once valuable, fail to account for the paradigm shift that MP has introduced. Likewise, commonly used donor- and recipient-based risk scores were developed prior to the adoption of MP. While these scores aim to assess survival or morbidity after transplantation, none of them guide decisions about MP use or the most suitable perfusion protocol. As MP technologies continue to evolve there is a critical need for an updated reference framework that accurately reflects current clinical practice and captures the best achievable outcomes across all MP modalities.
CONDITIONS
Official Title
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmortem donor livers accepted for transplantation in patients older than 18 years
- All donor types included (donation after brain death or circulatory death)
- Preservation using static cold storage alone or combined with machine perfusion
- Donor livers underwent machine perfusion as part of routine clinical practice
- Eligible machine perfusion protocols include end-ischemic hypothermic oxygenated MP, end-ischemic normothermic MP, continuous normothermic MP, hypothermic oxygenated MP followed by rewarming and normothermic MP, and normothermic regional perfusion followed by static cold storage or ex situ MP
- Minimum follow-up of 12 months after liver transplantation required
You will not qualify if you...
- Livers assigned to machine perfusion as part of a randomized or interventional clinical trial
- Living donor liver transplantation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
A.O.U. Città della Salute e della Scienza
Torino, Italy
Actively Recruiting
2
University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands
Actively Recruiting
Research Team
S
Sabrina Stimmeder, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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