Actively Recruiting
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
Led by Columbia University · Updated on 2026-04-09
106
Participants Needed
3
Research Sites
204 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
S
Stevens Institute of Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is (1) to identify disease specific walking-related digital biomarkers of disease severity, and (2) monitor longitudinal changes in natural environments, for extended periods of time, in DMD and SMA.
CONDITIONS
Official Title
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Genetic confirmation of Duchenne muscular dystrophy, spinal muscular atrophy type 3, or healthy control status
- Ability to walk independently for at least 25 meters
- For Duchenne muscular dystrophy: ongoing corticosteroid therapy or started corticosteroid therapy within the previous 3 months
- For spinal muscular atrophy: stable dose of FDA approved SMN up-regulator therapy or participation in an open-label extension phase of a study treatment for at least 6 months, or gene replacement therapy at enrollment
You will not qualify if you...
- Use of foot orthoses or assistive devices for walking in the community, or use of mobility devices for navigation
- Use of investigational medications intended to treat neuromuscular diseases within 30 days before study entry
- Injury or surgery affecting gait within 3 months prior to study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
2
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
3
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
J
Jacqueline Montes, PT, EdD
CONTACT
C
Cara Kanner, DPT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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