Actively Recruiting
Establishment and Clinical Application of Reference Intervals of Salivary Cortisol
Led by Shanghai 6th People's Hospital · Updated on 2025-09-11
220
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to establish the normal reference intervals of salivary cortisol and optimal cut-offs for Cushing's sydrome and adrenal insufficiency.
CONDITIONS
Official Title
Establishment and Clinical Application of Reference Intervals of Salivary Cortisol
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years for healthy volunteers
- Body mass index (BMI) between 18.5 and 24.9 kg/m2
- No history of chronic diseases such as hyperglycemia, hypertension, dyslipidemia, coronary heart disease, or stroke
- Normal glucose regulation: fasting blood glucose below 5.6 mmol/L, 2-hour blood glucose after glucose load below 7.8 mmol/L, and glycated hemoglobin (HbA1c) below 5.7%
- Age between 18 and 80 years for patients with suspected Cushing's syndrome or adrenal insufficiency
You will not qualify if you...
- Liver or kidney dysfunction with elevated liver enzymes or serum creatinine above 115 bcmol/L
- Pregnancy or breastfeeding, cancer, or mental illness
- Conditions affecting cortisol levels such as hypothalamus-pituitary-adrenal axis disease, autoimmune diseases, diagnosed mental diseases, Alzheimer's disease, alcoholism (alcohol over 60 g/day for men or over 40 g/day for women), or corticosteroid therapy in the past 3 months (including contraceptives or estrogen in females)
- Serious oral problems affecting saliva collection such as oral ulcers or gingival bleeding
- Night shift workers awake from 11:00 PM to 7:00 AM
- Acute infection with body temperature 37.3 �b0C or higher or C-reactive protein over 50 mg/L
- Corticosteroid therapy within the last 6 weeks for patients
- Severe liver and kidney dysfunction
- Alcoholism, depression, or other psychiatric disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Sixth People's Hospital
Shanghai, Shanghai Municipality, China, 200233
Actively Recruiting
Research Team
J
Jian Zhou, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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