Actively Recruiting
Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy
Led by Shanghai Changzheng Hospital · Updated on 2025-06-24
150
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter (Graves disease, GD). The clinical manifestations of TAO are complex and varied. In severe cases, it may seriously impair visual function, affect daily life, and even cause corneal ulceration, perforation, and blindness. Therefore, a reasonable and effective treatment plan should be chosen according to the degree of TAO. The aim of this clinical study is to: 1. Found the new diagnostic markers or imaging sequences. 2. Establish and validate a multimodal and multiparameter prediction model for moderate to severe TAO.
CONDITIONS
Official Title
Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with thyroid-associated ophthalmopathy (TAO) at the study hospital after August 31, 2024, based on Bartley criteria
- Moderate to severe TAO as defined by EUGOGO guidelines
- Clinical activity score (CAS) of 3 or higher on the 7-item scale for the study eye
You will not qualify if you...
- Need for immediate treatment due to sight-threatening complications or rapid vision worsening
- History of systemic steroid use exceeding 1 g methylprednisolone equivalent for TAO
- Any major illness or unstable condition increasing risk or affecting safety assessment
- Any condition impairing ability to comply with study procedures or data interpretation
- Currently pregnant or breastfeeding
- Any condition preventing orbital MRI
- Incomplete medical information
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Changzheng Hospital
Shanghai, Shanghai Municipality, China, 200003
Actively Recruiting
Research Team
T
Tuo Dr. Li, Vice Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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