Actively Recruiting
Estradiol and Intrusive Memories
Led by Charite University, Berlin, Germany · Updated on 2026-02-19
273
Participants Needed
1
Research Sites
184 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.
CONDITIONS
Official Title
Estradiol and Intrusive Memories
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy female volunteers
- German language proficiency at B1 level
- Age between 18 and 45 years
You will not qualify if you...
- Current or past mental disorder diagnosed by DSM-5
- Any physical illness
- Taking any medication except oral contraceptives
- History of traumatic experiences such as sexual abuse or rape
- Pregnancy or breastfeeding
- Use of oral contraceptives
- Currently in the follicular phase of the menstrual cycle
AI-Screening
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Trial Site Locations
Total: 1 location
1
Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany, 12203
Actively Recruiting
Research Team
T
Tolou Maslahati, M.Sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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