Actively Recruiting
Estradiol Plus Olaparib for Breast Cancer (PHOEBE)
Led by Mary D Chamberlin · Updated on 2025-11-20
6
Participants Needed
1
Research Sites
228 weeks
Total Duration
On this page
Sponsors
M
Mary D Chamberlin
Lead Sponsor
D
Dartmouth-Hitchcock Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Determine the safety and recommended Phase II dose of olaparib in combination with 17b-estradiol in post-menopausal patients with advanced ER+/HER2- breast cancer.
CONDITIONS
Official Title
Estradiol Plus Olaparib for Breast Cancer (PHOEBE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post-menopausal women with ER+/HER2- breast cancer
- Metastatic or locoregional recurrence not curable with current treatments
- Received at least one prior endocrine-based therapy in the advanced or metastatic setting
You will not qualify if you...
- No concurrent anti-cancer therapies allowed during study except anti-resorptive bone therapies (e.g., bisphosphonates, denosumab)
- Any investigational cancer therapy or systemic chemotherapy within the last 3 weeks
- Any radiation therapy within the last 2 weeks
- Known central nervous system disease unless clinically stable for 3 months or more
- Use of strong or moderate CYP3A inhibitors
- Persistent side effects of grade 2 or higher caused by previous cancer therapy
- History of deep venous thrombosis, pulmonary embolism, stroke, acute myocardial infarction, or congestive heart failure
- Previous cancer not treated with curative intent or with a recurrence risk of 30% or higher
- Severe kidney impairment with creatinine clearance of 30 mL/min or less
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
Research Team
R
Research Nurse
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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