Actively Recruiting
The Eswatini PRISM Study on Adolescents Living With HIV
Led by Eswatini Nazarene Health Institutions · Updated on 2025-12-04
140
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
E
Eswatini Nazarene Health Institutions
Lead Sponsor
B
Baylor College of Medicine Children's Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adolescents living with Human Immunodeficiency Virus (ALHIV) are at an increased risk of experiencing psychological distress and adverse mental health outcomes, particularly in low- to middle-income countries (LMICs). Although interventions aimed at promoting resilience have demonstrated potential in enhancing psychosocial outcomes among adolescents with chronic illnesses in high-income settings, there is a paucity of evidence from LMICs. This study protocol aims to outline a comprehensive framework for evaluating the feasibility, acceptability, and effectiveness of the Promoting Resilience in Stress Management (PRISM) intervention in comparison to standard psychosocial care among ALHIV in a LMIC, such as Eswatini (formerly known as Swaziland). Additionally, it seeks to gather qualitative insights from both participants and PRISM coaches regarding the PRISM program. Exploratory outcomes under investigation are psychological distress, resilience, and HIV health-related quality of life. We hypothesise that: 1. Participants in the PRISM intervention group will experience reduced psychological distress compared to those in the control arm. 2. Participants in the PRISM intervention group will report improved HIV health-related quality of life after receiving the intervention compared to the control group. 3. Participants in the intervention arm will have higher resilience scores after receiving the intervention compared to those receiving usual psychosocial care.
CONDITIONS
Official Title
The Eswatini PRISM Study on Adolescents Living With HIV
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents living with HIV aged 10-19 years
- Cognitively able to participate in interviews based on medical history
- Score greater than 13 on the Kessler Screening Scale for Psychological Distress (K6)
You will not qualify if you...
- Adolescents who refuse to participate
- Adolescents under 18 whose parents or caretakers do not consent
- Adolescents reporting suicidal thoughts in the last 30 days
- Parents or caretakers refusing to participate when invited
- Participants or PRISM coaches unwilling to provide informed consent for interviews
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Raleigh Fitkin Memorial Hospital-Baylor College of Medicine Children's Foundation Clinic
Manzini, Manzini Region, Eswatini, M200
Actively Recruiting
Research Team
M
Musa L. Nhlabatsi, MSc
CONTACT
M
Mduduzi C. Shongwe, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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