Actively Recruiting
FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
Led by Tianjin Huanhu Hospital · Updated on 2026-03-10
700
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to better understand freezing of gait (FOG), a disabling walking problem that occurs in Parkinson's disease and related neurological conditions. It is a prospective, multicenter, observational patient registry designed to collect long-term clinical information from adults with FOG or gait and balance problems. The study includes participants with Parkinson's disease and other related disorders to explore how different causes of FOG relate to symptoms, walking patterns, falls, disease progression, and outcomes over time. Participants are grouped into those with FOG at baseline and those at high risk for developing it. All receive standard medical care determined by their own physicians, with no experimental treatments assigned. Clinical data are collected during routine visits and follow-ups, including questionnaires, gait and balance evaluations, video recordings, and other common clinical tests over up to 36 months. During the study, participants will undergo various assessments such as clinician-rated scales, objective gait and balance tests, and video evaluations. Researchers will monitor changes in FOG severity, time to first FOG event, falls frequency, quality of life, gait speed, stride length, gait variability, balance performance, and brain connectivity using resting-state functional MRI. The study helps improve risk assessment for falls and informs future research on gait disorders.
CONDITIONS
Brief Title
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 30 to 85 years
- Presence of freezing of gait or gait or balance impairment
- Diagnosis of Parkinson's disease or related parkinsonian disorders including PSP, MSA, DLB, CBD, vascular parkinsonism, or idiopathic normal pressure hydrocephalus
- Ability to complete gait and balance assessments independently or with assistance
- Ability and willingness to provide written informed consent
You will not qualify if you...
- Severe dementia with Mini-Mental State Examination score less than 10
- Severe psychiatric disorders interfering with participation
- Severe cardiopulmonary, musculoskeletal, or other medical conditions significantly affecting gait safety
- Stroke, fracture, or other major medical events within the past 3 months
- Inability to comply with follow-up procedures
- Refusal of video or speech data collection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 36 months
Participants who undergo routine clinical care are observed over time with scheduled follow-up visits to collect clinical data on gait, balance, and freezing of gait severity.
Baseline visit and scheduled follow-up visits over 36 months
Trial Site Locations
Total: 1 location
1
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China, 300350
Actively Recruiting
Research Team
P
Peipei Liu, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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