Actively Recruiting
European Blood Pressure Intensive Control After Stroke
Led by University College Dublin · Updated on 2024-07-11
142
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
Sponsors
U
University College Dublin
Lead Sponsor
S
St Vincent's University Hospital, Ireland
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stroke is the third most common cause of death worldwide and the leading cause of disability. High blood pressure is an important risk factor for stroke. Lowering a person's blood pressure reduces the risk of future stroke or heart attack, and current guidelines recommend treatment to a target of \<130mmHg for secondary prevention. Home blood pressure measurement and telemonitoring are acceptable to patients, but there is uncertainty over the use of out of office blood pressure measurements in stroke patients in guidelines. This is a study designed to establish the feasibility of a larger clinical trial, comparing home blood pressure monitoring, telemonitoring and medication titration with standard care. The study hypothesis is that home BP measurement and telemonitoring with medication titration may lead to improved BP control compared to standard of care clinical practice.
CONDITIONS
Official Title
European Blood Pressure Intensive Control After Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Recent ischemic stroke or high-risk transient ischemic attack confirmed by brain CT or MRI
- Living at home and independent, able to walk without help but may need some assistance with daily activities
- Systolic blood pressure of 140 mmHg or higher at study entry
- Stroke or TIA event occurred between 30 days and 1 year before randomisation
- Kidney function with estimated glomerular filtration rate (eGFR) of 50 ml/min/m2 or higher within 3 months before randomisation
- Medically stable and able to participate in home blood pressure monitoring and the trial as assessed by the study doctor
- Willing and able to provide informed consent personally
You will not qualify if you...
- Systolic blood pressure below 110 mmHg after standing for 3 minutes or other reason the doctor advises against intensive blood pressure lowering (such as dizziness, fainting, or falls)
- Stroke caused by brain hemorrhage, cardio-embolism, or other specific causes like dissection or infection
- Severe narrowing or blockage (over 70%) of major neck or brain arteries
- Severe or life-threatening illnesses, such as dementia, active cancer, severe frailty, or other factors making study participation unlikely
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mater Misericordiae University Hospital
Dublin, Ireland
Actively Recruiting
Research Team
K
Katrina Tobin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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