European Blood Pressure Intensive Control After Stroke - Pilot Trial

What this Trial Is About

Stroke is a leading cause of death and disability worldwide, with high blood pressure being a major risk factor for stroke recurrence and cardiovascular events. This research aims to evaluate whether home blood pressure monitoring combined with telemonitoring and medication adjustment can better control blood pressure compared to standard office-based care in patients who have recently experienced an ischemic stroke or transient ischemic attack (TIA). The study is a phase 2 pilot trial designed to assess feasibility for a larger future study. Participants will be randomly assigned to one of two groups: one group will use home blood pressure measurement and telemonitoring alongside medication titration guided by a treatment algorithm, while the other group will receive standard blood pressure management by their physician according to current guidelines. Medication choices include diuretics, ACE inhibitors, and calcium-channel blockers, with regular review and adjustments made based on blood pressure readings. The study is conducted over a 12-month period. During the study, participants will have their blood pressure monitored regularly at home or in the office, with the research team reviewing data to guide treatment. Outcomes measured include differences in average systolic blood pressure after 12 months, the proportion of patients reaching target blood pressure, time taken to reach targets, adverse events, quality of life, cognitive changes, and patient feedback. Safety and adherence will also be monitored throughout the trial, which is sponsored by University College Dublin.

European Blood Pressure Intensive Control After Stroke