Actively Recruiting
An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis
Led by Radboud University Medical Center · Updated on 2025-04-23
700
Participants Needed
1
Research Sites
300 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Endoscopic retrograde cholangiopancreatography (ERCP) comes with a risk for post-ERCP pancreatitis (PEP), which accounts for considerable morbidity, high healthcare expenditure, and death. The pathophysiology of PEP and the underpinnings of the preventive effect of rectal NSAID (RN) is poorly understood. Guidelines advise to take preventive measures with a single dose of 100mg RN, peri-ERCP. While NSAID administration reduces the risk with 40%, PEP still occurs after ERCP. In addition, patients with a PEP history have a higher risk to develop recurrence after a subsequent ERCP. This might suggest that an underlying genetic risk may contribute to increasing the incidence of PEP in some patients.
CONDITIONS
Official Title
An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63; 18 years
- Written informed consent
- Indication to undergo an ERCP
You will not qualify if you...
- Pancreatic cancer
- Chronic pancreatitis
- Ongoing acute pancreatitis
- Altered anatomy where bile or pancreatic juices do not enter the duodenum via the ampulla of Vater
AI-Screening
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Trial Site Locations
Total: 1 location
1
RadboudUMC
Nijmegen, Gelderland, Netherlands, 6525 GA
Actively Recruiting
Research Team
M
Mike de Jong, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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