Actively Recruiting
A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)
Led by Aarhus University Hospital · Updated on 2025-12-04
1652
Participants Needed
14
Research Sites
735 weeks
Total Duration
On this page
Sponsors
A
Aarhus University Hospital
Lead Sponsor
R
Rigshospitalet, Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs). These are usually found by chance when people have scans for things like headaches or dizziness. Although CBIs don't cause symptoms at the time, they are linked to a higher risk of future stroke and death. There is currently no standard treatment for CBIs, and doctors have different approaches-some give stroke-preventing medication (like antiplatelets or statins), while others don't treat at all. This is mostly because there isn't enough research yet. This study will test whether stroke-preventing treatments help people with CBIs. It will also look at whether having a CBI increases the risk of dementia, and whether treatment might lower that risk.
CONDITIONS
Official Title
A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- MRI shows a lacunar infarct without prior stroke or TIA symptoms, characterized by a specific fluid-filled brain lesion between 3 and 15 mm with certain MRI features, OR
- MRI shows a cortical infarct without prior stroke or TIA symptoms, defined as a fluid-filled cavity or T2/FLAIR lesions with presumed vascular origin in cortical regions
- Life expectancy greater than 12 months
- Mostly independent in daily activities with a modified Rankin Scale (mRS) score of 3 or less
- Age 50 years or older
You will not qualify if you...
- History of stroke or transient ischemic attack (TIA)
- High risk of bleeding, including recent or recurrent gastrointestinal or genitourinary bleeding with significant hemoglobin drop, active peptic ulcer disease, or MRI evidence of cortical siderosis or prior lobar hemorrhage
- Need for long-term anticoagulant use for conditions such as deep vein thrombosis, pulmonary embolism, atrial fibrillation, mechanical heart valve, or antiphospholipid antibody syndrome
- Current need for lipid-lowering or platelet-inhibitor treatment for secondary cardiovascular prevention, including ischemic heart disease, recent stenting, ischemic stroke, revascularization surgeries, or lower-extremity arterial disease
- Co-existing progressive neurodegenerative diseases including dementia or Parkinson's disease
- Uncontrolled cancer or cancer associated with increased bleeding risk
- Already taking antiplatelet or anticoagulant medications regardless of the reason
- Women with menopause less than 12 months ago unless a negative pregnancy test has been confirmed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Aalborg Universitetshospital
Aalborg, Denmark, 9000
Not Yet Recruiting
2
Aarhus Universitetshospital
Aarhus, Denmark, 8200
Not Yet Recruiting
3
Aarhus University Hospital
Aarhus, Denmark, 8200
Actively Recruiting
4
Rigshospitalet
Copenhagen, Denmark, 2100
Not Yet Recruiting
5
Bispebjerg og Frederiksberg Hospital
Copenhagen, Denmark, 2400
Not Yet Recruiting
6
Herlev Hospital
Herlev, Denmark, 2730
Not Yet Recruiting
7
Regionshospitalet Gødstrup
Herning, Denmark, 7400
Not Yet Recruiting
8
Kolding Hospital
Kolding, Denmark, 6000
Not Yet Recruiting
9
Odense Universitetshospital
Odense, Denmark, 5000
Not Yet Recruiting
10
Roskilde Hospital
Roskilde, Denmark, 4000
Not Yet Recruiting
11
University Medical Center Hamburg-Eppendorf
Hamburg, Germany, 20246
Not Yet Recruiting
12
Oslo University Hospital
Oslo, Norway, 0450
Not Yet Recruiting
13
Skånes Universitetssjukhus
Lund, Sweden, 22242
Not Yet Recruiting
14
Universitätsspital - Inselspital - University of Bern
Bern, Switzerland, 3010
Not Yet Recruiting
Research Team
R
Rolf Blauenfeldt
CONTACT
I
Ida Thingholm Norup
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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