International Study on Fibromuscular Dysplasia and Related Arterial Diseases Aiming to Understand Genetic and Clinical Features

What this Trial Is About

Fibromuscular dysplasia FMD is a condition affecting the muscles in arterial walls, causing narrowing in small and medium arteries. It includes multifocal FMD with alternating narrowings and dilations, and focal FMD with a single narrowing. This research aims to study FMD and related conditions like Spontaneous Coronary Artery Dissection SCAD and atypical FMD across many countries, focusing on patient demographics, disease characteristics, and underlying genetic and molecular factors. The study involves collecting standard clinical data from patients diagnosed with FMD, both retrospectively and during regular follow-up visits. Participants may also choose to provide blood, urine, and in some cases, tissue samples for genetic and proteomic analysis to identify biomarkers. Enrollment occurs at centers in over 20 countries, enabling a global perspective on the disease. During the study, researchers will analyze patient information and biological samples to understand FMDs progression and its genetic and molecular basis. The main outcome is a wide-scale analysis of disease features and progression over 10 years. Participants will undergo standard care visits, and data collection will continue throughout the study, with optional biobanking for additional research.

European/International FMD Registry and Initiative