Actively Recruiting
EUS-CPN With and Without Bupivacaine
Led by Centre hospitalier de l'Université de Montréal (CHUM) · Updated on 2026-04-23
180
Participants Needed
1
Research Sites
425 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Endoscopic ultrasound (EUS) allows EUS-guided trans gastric injection of absolute alcohol around the base of the celiac plexus (celiac plexus neurolysis (EUS-CPN)), to help alleviate pain associated with pancreatic cancer. It is standard procedure to inject bupivacaine immediately before injecting absolute alcohol, to theoretically prevent pain that may occur during and after the procedure. However, there are no data showing whether bupivacaine injection has any real influence on intra-procedural, immediate post-procedural, or long-term pain control. The injection of bupivacaine before the alcohol may have no effect, a synergistic effect, or an antagonistic effect, by diluting the alcohol, and reducing its neurolytic capacity. Inadvertent intravascular injection of bupivacaine may also cause irreversible cardiac arrhythmias and death. The investigators therefore propose a randomized clinical trial to determine whether the exclusion of bupivacaine during EUS-guided CPN improves outcomes, or not.
CONDITIONS
Official Title
EUS-CPN With and Without Bupivacaine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Malignant-appearing pancreatic mass or proven pancreatic cancer involving the pancreatic genu, body, or tail
- Any level of abdominal or back pain possibly related to the mass, including new onset pain under 3 months, constant pain, centrally located pain, with or without radiation to the back, and no other obvious pain source
- No possibility of surgical management
- Signed informed consent
- Celiac axis accessible for bilateral neurolysis at endoscopic ultrasound
You will not qualify if you...
- Allergy to bupivacaine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre de recherche du Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
Research Team
C
CHARLES MACKAY, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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