Actively Recruiting
EUS Guided HVA and PVA for Circulating Tumor DNA in Patients
Led by Chinese University of Hong Kong · Updated on 2021-03-04
60
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The discovery of cell-free circulating tumor DNA (crDNA) in blood and the maturation of technologies for ctDNA analysis have presented an attractive opportunity for minimally invasive "liquid biopsy" genomic diagnostics. The investigators plan to perform EUS-guided portal vein and hepatic vein aspiration in GI cancers patients. The aim of the current study is thus to examine the concentration of ctDNA in portal vein (EUS-guided PVA), hepatic vein (EUS-guided HVA) and peripheral blood to understand the first pass effect of the liver with gastrointestinal (GI) cancers, and the possibility of using ctDNA as a marker for preoperative staging, restaging after neoadjuvant chemotherapy, and monitoring for recurrence.
CONDITIONS
Official Title
EUS Guided HVA and PVA for Circulating Tumor DNA in Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Newly diagnosed stage II-IV distal gastric cancer, pancreatic cancer, or colorectal cancer
- Undergoing treatment with surgery, neoadjuvant chemotherapy, neoadjuvant chemoirradiation, or palliative chemotherapy/immunotherapy
You will not qualify if you...
- Presence of synchronous cancer at other sites
- Tumors located at cardia, high lesser curve, or oesophagogastric junction
- Bulky lymph nodes at lesser curve or coeliac region preventing clear EUS puncture site
- Coagulopathy with INR >1.3 or partial thromboplastin time more than twice control
- Platelet count less than 50,000 x 10^3/uL
- Unwillingness to undergo follow-up assessments
- Liver cirrhosis, portal hypertension, or gastric varices
- Refusal to participate in the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
S
Shannon Chan, FRCSEd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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