Actively Recruiting
EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.
Led by Chinese University of Hong Kong · Updated on 2026-03-20
160
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the current study is to assess if EUS-PPGM could predict the treatment response and outcomes of varices to endoscopic variceal ligation (EVL) in patients with chronic hepatitis. The hypothesis is that a high EUS-PPGM value at 3 months correlates with the presence of varices requiring EVL in patients that have received primary or secondary variceal prophylaxis on 1 year follow-up upper endoscopy.
CONDITIONS
Official Title
EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 to 75 years old
- Provided informed consent
- Diagnosed with chronic hepatitis-induced cirrhosis
- Have esophageal varices and have received endoscopic variceal ligation (EVL) either as primary prophylaxis during variceal surveillance or as secondary prophylaxis after active variceal bleeding
- Or have bleeding gastric varices treated with endoscopic cyanoacrylate injection
You will not qualify if you...
- Medical Child-Pugh Class C
- Uncorrected platelet count below 50,000
- INR greater than 1.5 (natural)
- History or current hepatic encephalopathy
- Current or history of hepatocellular carcinoma
- Main portal vein thrombosis
- Anatomical alterations of hepatic vasculature preventing access to portal or hepatic veins
- History of spontaneous bacterial peritonitis within the previous three months
- Portopulmonary hypertension
- Cardiac decompensation
- Presence of ascites blocking the needle path between gastrointestinal tract and liver
- Presence of gastric or duodenal ulcers, Dieulafoy's lesion, or cancers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chinese University of Hong Kong
Hong Kong, Hong Kong, China
Actively Recruiting
Research Team
A
Anthony Teoh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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