Actively Recruiting
EUS-RFA PANCARDINAL-1 Trial
Led by The University of Texas Health Science Center, Houston · Updated on 2025-05-21
60
Participants Needed
1
Research Sites
354 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objectives of this study are to determine the feasibility, tolerability, and treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus standard-of-care neoadjuvant chemotherapy (NAC) in the treatment of pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound (EUS) radiofrequency ablation (RFA) and neoadjuvant chemotherapy (NAC) will be performed before tumor resection surgery, with the goal of shrinking a tumor or stopping the spread of cancer so that surgery might be less invasive and more effective.
CONDITIONS
Official Title
EUS-RFA PANCARDINAL-1 Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed and histologically-confirmed pancreatic ductal adenocarcinoma by biopsy
- Have a permanent street address
- Consent to study participation
- Have an axial CT scan consistent with pancreatic ductal adenocarcinoma
- No prior chemotherapy or less than 2 months of pre-operative chemotherapy for pancreatic ductal adenocarcinoma
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
You will not qualify if you...
- Younger than 18 years of age
- No permanent street address or telephone number
- Pregnant patients
- Inmates or prisoners
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Memorial Hermann Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Sofia C Colon, BS
CONTACT
N
Nirav Thosani, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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