Actively Recruiting
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Led by Johns Hopkins University · Updated on 2025-08-06
20
Participants Needed
1
Research Sites
292 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
T
The Richman Family Precision Medicine Center of Excellence in Alzheimer Disease
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
CONDITIONS
Official Title
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of mild cognitive impairment (MCI) with Clinical Dementia Rating of 0.5 or 1.0
- Cognitive scores more than 1.5 standard deviations below age-education norms in memory, processing speed, executive function, or language
- No history of dementia
- Not currently taking statins or taken statins in the last 6 months
- Cognitive or functional impairment not due to another neurological disease or delirium
You will not qualify if you...
- Currently taking statins or have taken statins in the last 6 months
- Contraindications to taking statins
- Transplant patients taking cyclosporine
- Unable to undergo MRI due to incompatible implants or metal
- Diagnosis of dementia by history
- Current substance abuse diagnosis
- Stroke or myocardial infarction within the past 6 months
- History of HIV infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins University, Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
S
Samantha Horn
CONTACT
R
Ritu Agarwal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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