Actively Recruiting
Evaluate the Safety and Efficacy of HL-1186 Tablet for Moderate to Severe Acute Pain After Surgery
Led by Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. · Updated on 2025-12-22
72
Participants Needed
1
Research Sites
20 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multiple-center, randomized, double-blind, placebo-controlled study design evaluating the safety, efficacy, and pharmacokinetics (PK) parameter of HL-1186 tablet for moderate to severe acute pain after surgery.
CONDITIONS
Official Title
Evaluate the Safety and Efficacy of HL-1186 Tablet for Moderate to Severe Acute Pain After Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Body Mass Index (BMI) between 18 kg/m2 and 30 kg/m2
- Scheduled for elective orthopedic, abdominal, or thoracic surgery under general anesthesia
- Able to understand the study and use pain scales, and communicate effectively
- Reported pain score of 4 or higher on the Numeric Rating Scale (NRS)
You will not qualify if you...
- Previous surgery at the same site affecting pain perception
- Allergy to any study drug components or related medications
- Use of prohibited medications within 5 half-lives or 7 days before randomization
- Certain heart conditions or unstable angina within screening period
- High risk of bleeding or bleeding disorders
- Pregnant or lactating women within 1 year postpartum
- Planning conception or unwilling to use effective contraception during study and 6 months after
- Participation in other clinical studies within 30 days before screening
- Other conditions judged by the investigator to prevent study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
Actively Recruiting
Research Team
R
Renhai Yang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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