Actively Recruiting
Evaluating Buspirone to Treat Opioid Withdrawal
Led by University of Maryland, Baltimore · Updated on 2026-05-01
100
Participants Needed
1
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this 10 to 12-day residential study, participants with OUD will be enrolled, stabilized on a short-acting opioid, undergo an opioid stepwise taper, and complete a post-taper observation period where participants will have the opportunity to initiate long-term buprenorphine or extended-release naltrexone.
CONDITIONS
Official Title
Evaluating Buspirone to Treat Opioid Withdrawal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 75 years
- Positive opioid urine test
- Current moderate to severe opioid use disorder with physical dependence
- Interested in undergoing opioid detoxification
You will not qualify if you...
- Pregnant or breastfeeding
- Enrolled in methadone or buprenorphine maintenance treatment
- Allergic to study medication or taking contraindicated medications such as CYP3A4 inhibitors or MAO inhibitors
- Significant mental health or physical disorder or life circumstance expected to interfere with participation
- Hypotension or prolonged QTc interval
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kahlert Institute for Addictino Medicin
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
C
Cecilia Bergeria, Ph.D.
CONTACT
C
Caitlyn Grubb, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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