Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06940479

Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis

Led by University of Colorado, Denver · Updated on 2026-03-24

46

Participants Needed

1

Research Sites

154 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if genicular artery embolization (GAE) can improve knee pain and decrease inflammation in adults with knee osteoarthritis. The main question it aims to answer is: \- Does the GAE procedure improve knee pain and decrease inflammation? Researchers will compare synovial fluid samples taken from the knee before and after the procedure. Participants will: * Have a contrast enhanced MRI before and after the procedure * Complete performance-based measures before and after the procedure * Complete questionnaires before and after the procedure

CONDITIONS

Official Title

Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Planned to undergo genicular artery embolization to treat knee osteoarthritis
  • Osteoarthritis confirmed by knee X-ray (Kellgren-Lawrence score 1-3) within the last 6 months
  • Persistent moderate to severe knee pain (visual analog scale >3) for at least 6 months
  • Pain not improved or intolerant to conservative treatments like analgesia, exercise, weight-loss, joint injections, or physical therapy
  • Body mass index (BMI) less than 35 kg/m2
  • Willingness to follow study procedures and availability for the study duration
Not Eligible

You will not qualify if you...

  • Blood clotting problems not controlled by treatment (INR >1.8 and platelets <50 x 10^9/L)
  • Taking anticoagulant medications that cannot be safely stopped for the procedure (e.g., aspirin for 5 days, Lovenox for 24 hours, Eliquis for 4-6 days depending on kidney function)
  • Allergy to iodinated contrast agents not relieved by steroid premedication
  • Active infection in the knee joint
  • Recent acute knee injury requiring surgery (fracture or ligament injury shown by MRI)
  • Previous total or partial knee replacement in the affected knee
  • Steroid injection inside the knee within the last 2 months
  • Untreated arterial or venous disease in the lower limbs
  • Medical conditions with life expectancy less than 6 months
  • Previous embolization procedure in the lower limbs
  • Kidney problems with estimated glomerular filtration rate (GFR) less than 45 ml/min and not on dialysis
  • Pregnant or planning to become pregnant within 6 months after the procedure
  • American Society of Anesthesiologists classification above 3
  • Less than 3 mm of synovial fluid in the lateral suprapatellar recess seen on MRI or ultrasound

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States, 80045

Actively Recruiting

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Research Team

S

Shireen Shikak, BS

CONTACT

T

Tricia Luna, MS, RN

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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