Study of Clonogenic Epithelial Cells in Patients with Bronchiolitis Obliterans Syndrome After Stem Cell or Lung Transplant

What this Trial Is About

This research aims to study abnormal clonogenic epithelial cells in patients with bronchiolitis obliterans syndrome BOS who have undergone either an allogeneic hematopoietic cell transplant or a lung transplant. By examining these cells, researchers hope to better understand BOS and improve early detection in future patients. The study involves participants from MD Anderson Cancer Center and Houston Methodist who have BOS and have undergone transplants. Participants will provide blood samples and undergo multiple airway brushings during their standard of care bronchoscopy procedure. After the bronchoscopy, they will have nasal brushings collected as well. Researchers will also review the participants medical records to gather additional data. This study does not involve any investigational drugs or treatment changes but focuses on biospecimen collection and chart review. During the study, participants will be monitored and followed for up to one year after their initial procedures. Researchers will measure the proportion of abnormal epithelial cells and compare epithelial cell populations among different transplant recipient groups. The study includes various assessments such as bronchoscopy, blood sample collection, nasal brushings, and medical record review to understand the cellular changes associated with BOS.

Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome