Actively Recruiting
Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome
Led by M.D. Anderson Cancer Center · Updated on 2026-03-11
15
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor stem cell transplant or a lung transplant. Learning more about clonogenic cells in these patients may help doctors to detect signs of bronchiolitis obliterans syndrome earlier in future patients.
CONDITIONS
Official Title
Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Allo-HCT recipients undergoing bronchoscopy at MD Anderson Cancer Center who consent to study airway brushings
- Patients with advanced BOS (FEV1 ≤ 75% predicted) meeting NIH criteria
- Patients with early BOS (≥ 10% decline in FEV1 but ≥ 75% predicted) with additional high-risk features
- Patients with no pulmonary impairment (FEV1 within 5% of baseline)
- Lung transplant recipients undergoing bronchoscopy at Houston Methodist who consent to study airway brushings
- Patients with BOS Stage 2 or higher (≥ 35% decline in FEV1 from baseline)
- Patients with BOS Stage 0p or 1 (10-35% decline in FEV1 from baseline)
- Patients undergoing screening bronchoscopy without FEV1 decline
- Patients with undiagnosed lung cancer or chronic obstructive pulmonary disease diagnosed by pulmonary function testing
You will not qualify if you...
- Bronchoscopy performed on an emergency basis for life-threatening issues
- Patients unwilling to give consent for study airway brushings
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
A
Ajay Sheshadri
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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